Loading...
|
Please use this identifier to cite or link to this item:
https://ir.cnu.edu.tw/handle/310902800/27777
|
Title: | Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla |
Authors: | Lin, Rong-Jyh Yen, Chuan-Min Chou, Tzung-Han Chiang, Feng-Yu Wang, Guey-Horng Tseng, Ya-Ping Wang, Lin Huang, Ting-Wei Wang, Hui-Chuan Chan, Leong-Perng Ding, Hsiou-Yu Liang, Chia-Hua |
Contributors: | 化妝品應用與管理系 |
Keywords: | Yakuchinone A Antioxidant Adipogenesis Apoptosis Hymenolepis Nana Anisakis Simplex |
Date: | 2013-09 |
Issue Date: | 2014-05-26 10:43:15 (UTC+8) |
Publisher: | Biomed Central Ltd |
Abstract: | Background: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities.Methods: Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated.Results: Yakuchinone A presents the ability of the removal of DPPH. and ABTS(+) free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor. (PPAR.). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana.Conclusions: In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana. |
Relation: | Bmc Complementary And Alternative Medicine, v.13 n.237 |
Appears in Collections: | [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
|
Files in This Item:
File |
Description |
Size | Format | |
index.html | | 0Kb | HTML | 1923 | View/Open |
|
All items in CNU IR are protected by copyright, with all rights reserved.
|