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| 標題: | Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla |
| 作者: | Lin, Rong-Jyh
Yen, Chuan-Min
Chou, Tzung-Han
Chiang, Feng-Yu
Wang, Guey-Horng
Tseng, Ya-Ping
Wang, Lin
Huang, Ting-Wei
Wang, Hui-Chuan
Chan, Leong-Perng
Ding, Hsiou-Yu
Liang, Chia-Hua |
| 貢獻者: | 化妝品應用與管理系 |
| 關鍵字: | Yakuchinone A
Antioxidant
Adipogenesis
Apoptosis
Hymenolepis Nana
Anisakis Simplex |
| 日期: | 2013-09 |
| 上傳時間: | 2014-05-26 10:43:15 (UTC+8) |
| 出版者: | Biomed Central Ltd |
| 摘要: | Background: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities.Methods: Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated.Results: Yakuchinone A presents the ability of the removal of DPPH. and ABTS(+) free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor. (PPAR.). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana.Conclusions: In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana. |
| 關聯: | Bmc Complementary And Alternative Medicine, v.13 n.237 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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