Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27777
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    標題: Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla
    作者: Lin, Rong-Jyh
    Yen, Chuan-Min
    Chou, Tzung-Han
    Chiang, Feng-Yu
    Wang, Guey-Horng
    Tseng, Ya-Ping
    Wang, Lin
    Huang, Ting-Wei
    Wang, Hui-Chuan
    Chan, Leong-Perng
    Ding, Hsiou-Yu
    Liang, Chia-Hua
    貢獻者: 化妝品應用與管理系
    關鍵字: Yakuchinone A
    Hymenolepis Nana
    Anisakis Simplex
    日期: 2013-09
    上傳時間: 2014-05-26 10:43:15 (UTC+8)
    出版者: Biomed Central Ltd
    摘要: Background: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities.Methods: Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated.Results: Yakuchinone A presents the ability of the removal of DPPH. and ABTS(+) free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor. (PPAR.). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana.Conclusions: In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana.
    關聯: Bmc Complementary And Alternative Medicine, v.13 n.237
    显示于类别:[化妝品應用與管理系(所)] 期刊論文


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