Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla

doi:10.1186/1472-6882-13-237

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/27777

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27777

Title:	Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla
Authors:	Lin, Rong-Jyh Yen, Chuan-Min Chou, Tzung-Han Chiang, Feng-Yu Wang, Guey-Horng Tseng, Ya-Ping Wang, Lin Huang, Ting-Wei Wang, Hui-Chuan Chan, Leong-Perng Ding, Hsiou-Yu Liang, Chia-Hua
Contributors:	化妝品應用與管理系
Keywords:	Yakuchinone A Antioxidant Adipogenesis Apoptosis Hymenolepis Nana Anisakis Simplex
Date:	2013-09
Issue Date:	2014-05-26 10:43:15 (UTC+8)
Publisher:	Biomed Central Ltd
Abstract:	Background: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities.Methods: Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated.Results: Yakuchinone A presents the ability of the removal of DPPH. and ABTS(+) free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor. (PPAR.). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana.Conclusions: In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana.
Relation:	Bmc Complementary And Alternative Medicine, v.13 n.237
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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