Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 藥學系(所) > 期刊論文 > Item 310902800/27684

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/27684

標題:	Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors
作者:	Somoza, Amber D. Lee, Kuan-Han Chiang, Yi-Ming Oakley, Berl R. Wang, Clay C.C.
貢獻者:	藥學系
關鍵字:	Oxidative Dearomatization Catalysis Product Acid
日期:	2012-02-17
上傳時間:	2014-03-21 16:17:35 (UTC+8)
出版者:	Amer Chemical Soc
摘要:	Sclerotiorin, an azaphilone polyketide, is a bioactive natural product known to inhibit 15-lipoxygenase and many other biological targets. To readily access sclerotiorin and analogs, we developed a 2-3 step semisynthetic route to produce a variety of azaphilones starting from an advanced, putative azaphilone intermediate (5) overproduced by an engineered strain of Aspergillus nidulans. The inhibitory activities of the semisynthetic azaphilones against 15-lipoxygenase were evaluated with several compounds displaying low micromolar potency.
關聯:	Organic Letters, 14(4), 972-975
顯示於類別:	[藥學系(所)] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	3182	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章