Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27684
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23355305      Online Users : 508
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27684


    Title: Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors
    Authors: Somoza, Amber D.
    Lee, Kuan-Han
    Chiang, Yi-Ming
    Oakley, Berl R.
    Wang, Clay C.C.
    Contributors: 藥學系
    Keywords: Oxidative Dearomatization
    Catalysis
    Product
    Acid
    Date: 2012-02-17
    Issue Date: 2014-03-21 16:17:35 (UTC+8)
    Publisher: Amer Chemical Soc
    Abstract: Sclerotiorin, an azaphilone polyketide, is a bioactive natural product known to inhibit 15-lipoxygenase and many other biological targets. To readily access sclerotiorin and analogs, we developed a 2-3 step semisynthetic route to produce a variety of azaphilones starting from an advanced, putative azaphilone intermediate (5) overproduced by an engineered strain of Aspergillus nidulans. The inhibitory activities of the semisynthetic azaphilones against 15-lipoxygenase were evaluated with several compounds displaying low micromolar potency.
    Relation: Organic Letters, 14(4), 972-975
    Appears in Collections:[Dept. of Pharmacy] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML2954View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback