Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors

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標題:	Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors
作者:	Somoza, Amber D. Lee, Kuan-Han Chiang, Yi-Ming Oakley, Berl R. Wang, Clay C.C.
貢獻者:	藥學系
關鍵字:	Oxidative Dearomatization Catalysis Product Acid
日期:	2012-02-17
上傳時間:	2014-03-21 16:17:35 (UTC+8)
出版者:	Amer Chemical Soc
摘要:	Sclerotiorin, an azaphilone polyketide, is a bioactive natural product known to inhibit 15-lipoxygenase and many other biological targets. To readily access sclerotiorin and analogs, we developed a 2-3 step semisynthetic route to produce a variety of azaphilones starting from an advanced, putative azaphilone intermediate (5) overproduced by an engineered strain of Aspergillus nidulans. The inhibitory activities of the semisynthetic azaphilones against 15-lipoxygenase were evaluated with several compounds displaying low micromolar potency.
關聯:	Organic Letters, 14(4), 972-975
显示于类别:	[藥學系(所)] 期刊論文

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