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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27684

    標題: Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors
    作者: Somoza, Amber D.
    Lee, Kuan-Han
    Chiang, Yi-Ming
    Oakley, Berl R.
    Wang, Clay C.C.
    貢獻者: 藥學系
    關鍵字: Oxidative Dearomatization
    日期: 2012-02-17
    上傳時間: 2014-03-21 16:17:35 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Sclerotiorin, an azaphilone polyketide, is a bioactive natural product known to inhibit 15-lipoxygenase and many other biological targets. To readily access sclerotiorin and analogs, we developed a 2-3 step semisynthetic route to produce a variety of azaphilones starting from an advanced, putative azaphilone intermediate (5) overproduced by an engineered strain of Aspergillus nidulans. The inhibitory activities of the semisynthetic azaphilones against 15-lipoxygenase were evaluated with several compounds displaying low micromolar potency.
    關聯: Organic Letters, 14(4), 972-975
    Appears in Collections:[藥學系(所)] 期刊論文

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