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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27510


    標題: Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress
    作者: Chen, Zong-Tsi
    Chu, Heuy-Ling
    Chyau, Charng-Cherng
    Chu, Chin-Chen
    Duh, Pin-Der
    貢獻者: 食品科技系
    醫藥化學系
    關鍵字: Cytoprotection
    Hesperidin
    Oxidative Stress
    Sweet Orange Peel
    日期: 2012-12-15
    上傳時間: 2014-03-21 16:11:53 (UTC+8)
    出版者: Elsevier Sci Ltd
    摘要: Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. Overall, WESP displayed a significant cytoprotective effect against oxidative stress, which may be most likely because of the phenolics-related bioactive compounds in WESP, leading to maintenance of the normal redox status of cells. (C) 2012 Elsevier Ltd. All rights reserved.
    關聯: Food Chemistry, 135(4), 2119-2127
    Appears in Collections:[ 食品科技系 ] 期刊論文
    [醫藥化學系 ] 期刊論文

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