Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress

doi:10.1016/j.foodchem.2012.07.041

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 食品科技系 > 期刊論文 > Item 310902800/27510

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標題:	Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress
作者:	Chen, Zong-Tsi Chu, Heuy-Ling Chyau, Charng-Cherng Chu, Chin-Chen Duh, Pin-Der
貢獻者:	食品科技系醫藥化學系
關鍵字:	Cytoprotection Hesperidin Oxidative Stress Sweet Orange Peel
日期:	2012-12-15
上傳時間:	2014-03-21 16:11:53 (UTC+8)
出版者:	Elsevier Sci Ltd
摘要:	Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. Overall, WESP displayed a significant cytoprotective effect against oxidative stress, which may be most likely because of the phenolics-related bioactive compounds in WESP, leading to maintenance of the normal redox status of cells. (C) 2012 Elsevier Ltd. All rights reserved.
關聯:	Food Chemistry, 135(4), 2119-2127
显示于类别:	[ 食品科技系 ] 期刊論文 [食藥產業暨檢測科技系(含五專)] 期刊論文

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