Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27510
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23354213      Online Users : 446
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27510


    Title: Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress
    Authors: Chen, Zong-Tsi
    Chu, Heuy-Ling
    Chyau, Charng-Cherng
    Chu, Chin-Chen
    Duh, Pin-Der
    Contributors: 食品科技系
    醫藥化學系
    Keywords: Cytoprotection
    Hesperidin
    Oxidative Stress
    Sweet Orange Peel
    Date: 2012-12-15
    Issue Date: 2014-03-21 16:11:53 (UTC+8)
    Publisher: Elsevier Sci Ltd
    Abstract: Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. Overall, WESP displayed a significant cytoprotective effect against oxidative stress, which may be most likely because of the phenolics-related bioactive compounds in WESP, leading to maintenance of the normal redox status of cells. (C) 2012 Elsevier Ltd. All rights reserved.
    Relation: Food Chemistry, 135(4), 2119-2127
    Appears in Collections:[Dept. of Food Science & Technology] Periodical Articles
    [Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML2219View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback