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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26669

    標題: Novel phenolic glucoside, origanoside, protects against oxidative damage and modulates antioxidant enzyme activity
    作者: Chou, Tzung-Han
    Ding, Hsiou-Yu
    Chan, Leong-Perng
    Liang, Jing-Yao
    Liang, Chia-Hua
    貢獻者: 化粧品科技研究所
    關鍵字: Antioxidant
    Origanum vulgare
    Oxidative stress
    日期: 2011-06
    上傳時間: 2013-06-03 15:52:51 (UTC+8)
    出版者: Elsevier
    摘要: Our previous research demonstrated that a novel phenolic glucoside, origanoside, isolated from Origanum vulgare, exhibits significant antimelanogenesis activity. The present study was designed to investigate whether origanoside may serve as a quencher of oxidative insults and is involved in antimelanogenesis. It is found that origanoside exhibit the radical-scavenging capacity of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+) and superoxide anion radical (O2−), the reducing power, and the inhibition ability of lipid peroxidation (LP). Pretreatment with origanoside in hydrogen peroxide (H2O2)-treated BNLCL2 and HaCaT cells increased the activities of catalase (CAT) and glutathione peroxidase (GPx), potentially reducing the amount of reactive oxygen species (ROS) generation. These findings confirm the cytoprotective effect of origanoside in hepatocytes and keratinocytes, suggesting that origanoside exhibits antioxidant activities and may be a useful food additive.
    關聯: Food Research International 44(5), pp. 1496-1503
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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