Novel phenolic glucoside, origanoside, protects against oxidative damage and modulates antioxidant enzyme activity

doi:10.1016/j.foodres.2011.03.041

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/26669

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/26669

Title:	Novel phenolic glucoside, origanoside, protects against oxidative damage and modulates antioxidant enzyme activity
Authors:	Chou, Tzung-Han Ding, Hsiou-Yu Chan, Leong-Perng Liang, Jing-Yao Liang, Chia-Hua
Contributors:	化粧品科技研究所化粧品應用與管理系
Keywords:	Antioxidant Origanoside Origanum vulgare Oxidative stress
Date:	2011-06
Issue Date:	2013-06-03 15:52:51 (UTC+8)
Publisher:	Elsevier
Abstract:	Our previous research demonstrated that a novel phenolic glucoside, origanoside, isolated from Origanum vulgare, exhibits significant antimelanogenesis activity. The present study was designed to investigate whether origanoside may serve as a quencher of oxidative insults and is involved in antimelanogenesis. It is found that origanoside exhibit the radical-scavenging capacity of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+) and superoxide anion radical (O2−), the reducing power, and the inhibition ability of lipid peroxidation (LP). Pretreatment with origanoside in hydrogen peroxide (H2O2)-treated BNLCL2 and HaCaT cells increased the activities of catalase (CAT) and glutathione peroxidase (GPx), potentially reducing the amount of reactive oxygen species (ROS) generation. These findings confirm the cytoprotective effect of origanoside in hepatocytes and keratinocytes, suggesting that origanoside exhibits antioxidant activities and may be a useful food additive.
Relation:	Food Research International 44(5), pp. 1496-1503
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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