Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/2405
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    標題: 以胃癌動物模式研究局部和周邊淋巴結的CD4+CD25+調節性T細胞免疫調控機轉
    Characteristics of CD4+CD25+ regulatory T cells in regional lymph nodes of mice with benzo[a]pyrene-induced forestomach carcinoma
    作者: 陳怡伶:Yi-Ling Chen
    貢獻者: 嬰幼兒保育系
    日期: 2005
    上傳時間: 2008-07-31 14:37:54 (UTC+8)
    出版者: 台南縣：嘉南藥理科技大學嬰幼兒保育系
    摘要: The increased populations of regulatory T cells in peripheral blood of gastric
    carcinoma reflect compromised host immunity. In this study, the murine model of
    benzo[a]pyrene induced forestomach carcinoma was used to analyze the distribution
    of regulatory T cells in different lymphoid tissues, including the regional lymph nodes,
    the peripheral lymph nodes, spleen, and thymus. The proportions of regulatory T cells
    in total CD4+ T cells is clearly more increased in regional lymph nodes than other
    lymphoid tissues in benzo[a]pyrene-treated mice. These regulatory T cells expressed
    the Foxp3 transcript and protein and were dramatically enhanced in regional lymph
    nodes relative to peripheral lymph nodes. They were also enriched in CD62L- cell
    subset and expressed both CCR1 and CCR5 chemokine receptors. These results
    demonstrate that the accumulation of Treg cells in the regional lymph nodes mediated
    local suppressive immunity during progression of forestomach tumours.
    關聯: 計畫編號：NSC94-2320-B-041-005
    显示于类别:[嬰幼兒保育系] 科技部計畫

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