以胃癌動物模式研究局部和周邊淋巴結的CD4+CD25+調節性T細胞免疫調控機轉

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Title:	以胃癌動物模式研究局部和周邊淋巴結的CD4+CD25+調節性T細胞免疫調控機轉 Characteristics of CD4+CD25+ regulatory T cells in regional lymph nodes of mice with benzo[a]pyrene-induced forestomach carcinoma
Authors:	陳怡伶:Yi-Ling Chen
Contributors:	嬰幼兒保育系
Date:	2005
Issue Date:	2008-07-31 14:37:54 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學嬰幼兒保育系
Abstract:	The increased populations of regulatory T cells in peripheral blood of gastric carcinoma reflect compromised host immunity. In this study, the murine model of benzo[a]pyrene induced forestomach carcinoma was used to analyze the distribution of regulatory T cells in different lymphoid tissues, including the regional lymph nodes, the peripheral lymph nodes, spleen, and thymus. The proportions of regulatory T cells in total CD4+ T cells is clearly more increased in regional lymph nodes than other lymphoid tissues in benzo[a]pyrene-treated mice. These regulatory T cells expressed the Foxp3 transcript and protein and were dramatically enhanced in regional lymph nodes relative to peripheral lymph nodes. They were also enriched in CD62L- cell subset and expressed both CCR1 and CCR5 chemokine receptors. These results demonstrate that the accumulation of Treg cells in the regional lymph nodes mediated local suppressive immunity during progression of forestomach tumours.
Relation:	計畫編號：NSC94-2320-B-041-005
Appears in Collections:	[Dept. of Childhood Education and Nursery] MOST Project

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