Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/2314
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    標題: 以胃腸道癌症的動物模式研究CD4+CD25+調節性 T 細胞的功能性
    Enhancement of CD4+CD25+ T cells in tumor growth of benzo[a]pyrene-induced forestomach carcinoma via suppression of local immunity
    作者: 陳怡伶;Yi-Ling Chen
    貢獻者: 嬰幼兒保育系
    日期: 2004
    上傳時間: 2008-07-25 16:35:11 (UTC+8)
    出版者: 台南縣：嘉南藥理科技大學嬰幼兒保育系
    摘要: The increased populations of Treg cells in peripheral blood and gastric carcinoma
    reflect compromised host immunity. It remains unclear, whether the Treg cells in the
    lymphoid tissues contribute to the immune dysfunction in gastric cancer. In this
    study, the murine model of benzo[a]pyrene(B[a]P)-induced forestomach carcinoma was
    used to analyze the distribution of Treg cell populations in different lymphoid tissues. To
    determine the enhancement of Treg cells on tumor growth, the Treg cells were depleted
    by PC61 specific antibody. The proportions of Treg cells in the thymus, spleen, the
    regional lymph nodes (nodes at the perigastric area and the mesentery, RLNs), and the
    peripheral lymph nodes (nodes at the axillary, inguinal, brachial, and popliteal, PLNs),
    were compared. The proportion of Treg cells in total CD4+ T cells is clearly increased in
    RLNs compared with PLNs, spleen and thymus in B[a]P-treated mice as tumor grown.
    Moreover, these cells express the Foxp3 transcript and were dramatically enhanced in
    RLNs relative to PLNs at 32 weeks. After depletion, the proportion of Treg cells
    decreased in the lymphoid tissues, especial in the RLNs, the tumor mass reduced
    significantly, and massive infiltrating cells at the tumor sites and apoptosis of the tumor
    masses were observed in the forestomach carcinomas of the B[a]p treated mice at 32
    weeks. These results demonstrate that the accumulation of Treg cells in the regional
    lymph nodes mediated suppressive immunity in progressive forestomach tumors. Treg
    cells depletion reduces growth of tumor via effective local immunity.
    關聯: 計畫編號：NSC93-2320-B041-010
    显示于类别:[嬰幼兒保育系] 科技部計畫

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