以胃腸道癌症的動物模式研究CD4+CD25+調節性 T 細胞的功能性

CNU IR > College of Smart Living > Dept. of Childhood Education and Nursery > MOST Project > Item 310902800/2314

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/2314

Title:	以胃腸道癌症的動物模式研究CD4+CD25+調節性 T 細胞的功能性 Enhancement of CD4+CD25+ T cells in tumor growth of benzo[a]pyrene-induced forestomach carcinoma via suppression of local immunity
Authors:	陳怡伶;Yi-Ling Chen
Contributors:	嬰幼兒保育系
Date:	2004
Issue Date:	2008-07-25 16:35:11 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學嬰幼兒保育系
Abstract:	The increased populations of Treg cells in peripheral blood and gastric carcinoma reflect compromised host immunity. It remains unclear, whether the Treg cells in the lymphoid tissues contribute to the immune dysfunction in gastric cancer. In this study, the murine model of benzo[a]pyrene(B[a]P)-induced forestomach carcinoma was used to analyze the distribution of Treg cell populations in different lymphoid tissues. To determine the enhancement of Treg cells on tumor growth, the Treg cells were depleted by PC61 specific antibody. The proportions of Treg cells in the thymus, spleen, the regional lymph nodes (nodes at the perigastric area and the mesentery, RLNs), and the peripheral lymph nodes (nodes at the axillary, inguinal, brachial, and popliteal, PLNs), were compared. The proportion of Treg cells in total CD4+ T cells is clearly increased in RLNs compared with PLNs, spleen and thymus in B[a]P-treated mice as tumor grown. Moreover, these cells express the Foxp3 transcript and were dramatically enhanced in RLNs relative to PLNs at 32 weeks. After depletion, the proportion of Treg cells decreased in the lymphoid tissues, especial in the RLNs, the tumor mass reduced significantly, and massive infiltrating cells at the tumor sites and apoptosis of the tumor masses were observed in the forestomach carcinomas of the B[a]p treated mice at 32 weeks. These results demonstrate that the accumulation of Treg cells in the regional lymph nodes mediated suppressive immunity in progressive forestomach tumors. Treg cells depletion reduces growth of tumor via effective local immunity.
Relation:	計畫編號：NSC93-2320-B041-010
Appears in Collections:	[Dept. of Childhood Education and Nursery] MOST Project

Files in This Item:

File	Description	Size	Format
NSC93-2320-B041-010.pdf		731Kb	Adobe PDF	1131	View/Open

Loading...