男性的掉髮模式目前的研究認為有95%的患者是雄性禿(androgenetic alopecia)，5 alpha 環原酶5 alpha-reductase進行催化睪素酮(Testosterone)反應，使得睪素酮轉換成更具效果的雄性素－二氫睪素酮(Dihydrotestosterone)，而造成雄性禿症狀。5alpha 1顯著於皮脂腺體，5alpha 2則顯著於頭皮毛囊。
研究內容可分成三部份(Ⅰ)評估不同濃度的細胞數目及不同的時間點來看14C-testosterone(14C-T)經由5 alpha reductase轉換為14C-dihydrotestosterone (14C-DHT)的活性分析，(Ⅱ)由 (Ⅰ)所得的最適當細胞濃度與時間來評估八種萃取物之T轉換為DHT的轉換率，(Ⅲ)由(Ⅱ)所得的結果中，挑選具有活性的成分以C57BL/6小鼠進行動物實驗。 Male pattern hair loss present study suggests that 95% of the patients are androgenetic alopecia, 5 alpha reductase (5 alpha-reductase) for catalytic Testosterone reaction, making one testis hormone into a more with effects of male hormone dihydrotestosterone, causing symptoms of male baldness. The 5alpha 1 significantly in the sebaceous glands, 5 alpha 2 significantly in the scalp hair follicles.
This study can be divided into three parts (Ⅰ) assess the number of cells in different concentrations and different time point of view 14C-testosterone (14C-T) by the 5 alpha reductase converted to 14C-dihydrotestosterone (14C-DHT) activity analysis, (Ⅱ) investigate the 5 alpha reductase inhibition effect of natural product extract by the optimum condition from (Ⅰ) , (Ⅲ)evaluate the hair growth effect of the natural product extract selected from (Ⅱ) by C57BL/6 mice experiment.
