Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/22518
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/22518


    標題: 數種天然萃取物應用於預防雄性禿保養品之細胞及動物評估
    Application and Evaluation of Several Natural Product Extracts on Prevention Androgenetic Alopecia by Cell and Animal Model
    作者: 許錦婷
    貢獻者: 林維炤
    嘉南藥理科技大學:化妝品科技研究所
    關鍵字: 雄性禿
    5 alpha 還原酶
    androgenetic alopecia
    5 alpha-reductase
    日期: 2009
    上傳時間: 2010-03-30 14:22:00 (UTC+8)
    摘要: 男性的掉髮模式目前的研究認為有95%的患者是雄性禿(androgenetic alopecia),5 alpha 環原酶5 alpha-reductase進行催化睪素酮(Testosterone)反應,使得睪素酮轉換成更具效果的雄性素-二氫睪素酮(Dihydrotestosterone),而造成雄性禿症狀。5alpha 1顯著於皮脂腺體,5alpha 2則顯著於頭皮毛囊。
    研究內容可分成三部份(Ⅰ)評估不同濃度的細胞數目及不同的時間點來看14C-testosterone(14C-T)經由5 alpha reductase轉換為14C-dihydrotestosterone (14C-DHT)的活性分析,(Ⅱ)由 (Ⅰ)所得的最適當細胞濃度與時間來評估八種萃取物之T轉換為DHT的轉換率,(Ⅲ)由(Ⅱ)所得的結果中,挑選具有活性的成分以C57BL/6小鼠進行動物實驗。
    Male pattern hair loss present study suggests that 95% of the patients are androgenetic alopecia, 5 alpha reductase (5 alpha-reductase) for catalytic Testosterone reaction, making one testis hormone into a more with effects of male hormone dihydrotestosterone, causing symptoms of male baldness. The 5alpha 1 significantly in the sebaceous glands, 5 alpha 2 significantly in the scalp hair follicles.
    This study can be divided into three parts (Ⅰ) assess the number of cells in different concentrations and different time point of view 14C-testosterone (14C-T) by the 5 alpha reductase converted to 14C-dihydrotestosterone (14C-DHT) activity analysis, (Ⅱ) investigate the 5 alpha reductase inhibition effect of natural product extract by the optimum condition from (Ⅰ) , (Ⅲ)evaluate the hair growth effect of the natural product extract selected from (Ⅱ) by C57BL/6 mice experiment.
    關聯: 校內校外均不公開,學年度:97,140頁
    显示于类别:[化妝品應用與管理系(所)] 博碩士論文

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