中草藥化粧品原料之開發與應用 (II)

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 校內計畫 > Item 310902800/521

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標題:	中草藥化粧品原料之開發與應用 (II)
作者:	丁秀玉
貢獻者:	化粧品科技研究所
關鍵字:	牡丹皮抗自由基酪氨酸酶抑制劑 Mudanpi free radical scanvenger tyrosinase inhibitor
日期:	2006
上傳時間:	2008-05-19 13:37:31 (UTC+8)
出版者:	台南縣：嘉南藥理科技大學化粧品科技研究所
摘要:	中藥牡丹皮 (Paeonia suffruticosa Andr.) 以生物活性指標導引純化分離有效成分，其結果得到具有掃除自由基DPPH的成分為2,5-Dihydroxy-4-methylacetophenone (1)、2,5-Dihydroxy-4-methoxyacetophenone (2)、Methyl gallate (4) 、Benzoic acid (5)、4-Hydroxy-3-methoxybenzoic acid (6)、Ethyl gallate (7) 、p-Hydroxybenzoic acid (8)及Gallic acid (9) 和抑制酪氨酸酶活性的成分為3-Hydroxy-4-methoxyacetophenone (3) 、Benzoic acid (5) 、Ethyl gallate (7) 及p-Hydroxybenzoic acid (8)。分離出化合物中4和7為首次自此植物中分離得到。化合物1、2、5和6為首次發現其具有將其應用在掃除自由基DPPH，化合物3、7和8為首次發現其具有抑制酪氨酸酶之活性。上述有效成分之化合物是經由光譜分析而確定其化學結構， Chinese herb” Mudanpi “ (root cortex of Paeonia suffruticosa Andr.) has been described to possess cosmetic activity in tradition Chinese medicine. The bioassay guided purification to get nine compounds. Among of isolated compounds, 2,5-Dihydroxy-4-methylacetophenone (1), 2,5-Dihydroxy-4-methoxyacetophenone (2), Methyl gallate (4), Benzoic acid (5), 4-Hydroxy-3-methoxybenzoic acid (6), Ethyl gallate (7), p-Hydroxybenzoic acid (8), and Gallic acid (9) show DPPH scavenging activity and 3-Hydroxy-4-methoxyacetophenone (3), Benzoic acid (5), Ethyl gallate (7), and p-Hydroxybenzoic acid (8) inhibit tyrosinase activity. Among the purified compounds, 4 and 7 were the first purified from plant; 1, 2, 5, and 6 were first identified with DPPH scavenging activity; 3, 7, and 8 were first identified as tyrosinase inhibitors. Their structures have been established on the basis of spectral evidences.
關聯:	計畫編號 : CNIC9505
显示于类别:	[化妝品應用與管理系(所)] 校內計畫

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