Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27822
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 16717/19012 (88%)
造访人次 : 5863181      在线人数 : 91
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/27822


    標題: Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters
    作者: Lee, Kuan-Han
    Lin, Yu-Sheng
    Huang, Po-Jui
    貢獻者: 藥學系
    關鍵字: Self-Assembled Monolayers
    Alkanethiolate Monolayers
    Nanoparticles
    Core
    Nanocrystals
    Molecules
    Dynamics
    Colloids
    Therapy
    Size
    日期: 2013
    上傳時間: 2014-05-26 10:45:04 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: A series of new thiol-derivatized ibuprofen monolayer protected gold clusters have been prepared by amidation of ibuprofen with alkyl alcohol or aminophenol affording the carboxamides, N-hydroxyalkyl amide 2, and N-hydroxyphenyl amide 6, which were then tosylated with p-toluenesulfonyl chloride at hydroxyl group to give 3 and 7. Reactions of 3 and 7 with NaSH afforded the mercapto derivatives 4 and 8. Conducting Brust's reaction with a 3 : 1 mole ratio of thiolate ibuprofen/AuCl4- yielded polydisperse thiol-derivatized ibuprofen-MPCs 5 and 9. All compounds have been identified by NMR, MS, UV, and IR spectroscopies. Compounds 4 and 8 and the MPCs 5 and 9 have been investigated by using the method of H-1 NMR spectroscopy. The broadening of the signals from 0.8 to 2.0 ppm in H-1 NMR spectrum of MPCs 5 and 9 confirmed the success of the conjugation of thiol-containing derivatives with nanogold cluster.
    關聯: Journal of Nanomaterials v. n. pp.931815-
    显示于类别:[藥學系(所)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML387检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈