Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27822
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    標題: Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters
    作者: Lee, Kuan-Han
    Lin, Yu-Sheng
    Huang, Po-Jui
    貢獻者: 藥學系
    關鍵字: Self-Assembled Monolayers
    Alkanethiolate Monolayers
    Nanoparticles
    Core
    Nanocrystals
    Molecules
    Dynamics
    Colloids
    Therapy
    Size
    日期: 2013
    上傳時間: 2014-05-26 10:45:04 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: A series of new thiol-derivatized ibuprofen monolayer protected gold clusters have been prepared by amidation of ibuprofen with alkyl alcohol or aminophenol affording the carboxamides, N-hydroxyalkyl amide 2, and N-hydroxyphenyl amide 6, which were then tosylated with p-toluenesulfonyl chloride at hydroxyl group to give 3 and 7. Reactions of 3 and 7 with NaSH afforded the mercapto derivatives 4 and 8. Conducting Brust's reaction with a 3 : 1 mole ratio of thiolate ibuprofen/AuCl4- yielded polydisperse thiol-derivatized ibuprofen-MPCs 5 and 9. All compounds have been identified by NMR, MS, UV, and IR spectroscopies. Compounds 4 and 8 and the MPCs 5 and 9 have been investigated by using the method of H-1 NMR spectroscopy. The broadening of the signals from 0.8 to 2.0 ppm in H-1 NMR spectrum of MPCs 5 and 9 confirmed the success of the conjugation of thiol-containing derivatives with nanogold cluster.
    顯示於類別:[藥學系(所)] 期刊論文

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