Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters

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Title:	Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters
Authors:	Lee, Kuan-Han Lin, Yu-Sheng Huang, Po-Jui
Contributors:	藥學系
Keywords:	Self-Assembled Monolayers Alkanethiolate Monolayers Nanoparticles Core Nanocrystals Molecules Dynamics Colloids Therapy Size
Date:	2013
Issue Date:	2014-05-26 10:45:04 (UTC+8)
Publisher:	Hindawi Publishing Corporation
Abstract:	A series of new thiol-derivatized ibuprofen monolayer protected gold clusters have been prepared by amidation of ibuprofen with alkyl alcohol or aminophenol affording the carboxamides, N-hydroxyalkyl amide 2, and N-hydroxyphenyl amide 6, which were then tosylated with p-toluenesulfonyl chloride at hydroxyl group to give 3 and 7. Reactions of 3 and 7 with NaSH afforded the mercapto derivatives 4 and 8. Conducting Brust's reaction with a 3 : 1 mole ratio of thiolate ibuprofen/AuCl4- yielded polydisperse thiol-derivatized ibuprofen-MPCs 5 and 9. All compounds have been identified by NMR, MS, UV, and IR spectroscopies. Compounds 4 and 8 and the MPCs 5 and 9 have been investigated by using the method of H-1 NMR spectroscopy. The broadening of the signals from 0.8 to 2.0 ppm in H-1 NMR spectrum of MPCs 5 and 9 confirmed the success of the conjugation of thiol-containing derivatives with nanogold cluster.
Relation:	Journal of Nanomaterials v. n. pp.931815-
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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