Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/970
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    標題: 以魚類肝臟初代細胞株探討環境中仿雌激素物質的可行性研究─總計劃
    其他標題: 子計劃1 : 都市處理廠放流水中仿雌激素活性之探討
    子計畫2 : 人工濕地放流水仿雌激素活性之探討
    子計畫3 : 底泥孔隙水中仿雌激素活性之探討
    作者: 陳健民
    貢獻者: 環境資源管理系
    關鍵字: 仿雌激素
    間隙水
    底泥
    xenoestrogen
    interstitial water
    sediment
    日期: 2004
    上傳時間: 2008-06-20 13:53:25 (UTC+8)
    出版者: 台南縣：嘉南藥理科技大學環境資源管理系
    摘要: 由於界面活性劑、殺蟲劑及塑化劑等物質之運用，使全球各地水體皆發現有環境荷爾蒙物質，此類物質會有類似一般生物體內荷爾蒙物質之作用，改變正常功能，亦稱為內分泌干擾物(endocrine disrupting chemicals，
    EDCs)，其對生物及人類之影響已引起注意。在環境荷爾蒙物質中最常被討論的物質為仿雌激素，其亦常出現於污染水域環境中，逐漸蓄積於底泥系統間隙水中而成為一污染源，並藉由分佈平衡現象而釋出回到水體。因此，以生物指標方法檢視環境中的此類物質即成為目前環境污染凡至工作之重要課題之一。本整合計畫採取不同的環境樣本，即經人工濕地系統處理後之進流與放流水、都市處理廠放流水、污染河川底泥的孔隙水等三種環境水樣，以青將魚(Japanese Medaka,
    Oryzias latips) 肝臟培養細胞中卵黃蛋白先質(vitellogenin, VTG）的表現檢視其雌激素的活性。實驗結果顯示除底泥間隙水水樣無法測試外，暴露於其他測試水皆有VTG 的表現，並與暴露時間之長短有相關。
    There are many EDCs found in the
    water around the world because of the
    usage of surfactants 、pesticides and
    plasticizer. These chemicals can disrupt
    normal hormonal functions in human
    and other organisms. These effects have
    already caused a lot of attention.
    Xenoestrogen is one of EDCs can be
    found in polluted water as well as in the
    sediment-system. Once xenoestrogen are
    transported into the sediments, the
    system acts as a reservoir and
    xenoestrogen can be released back to the
    water because the partitioning effect.
    Therefore, developing biomarkers to
    detect such EDCs in different
    environmental matrix became a major
    issue. The purpose of this project was to
    examine the activity of xenoestrogen in
    the different environmental samples,
    namely effluents from a constructed
    wetland, a municipal sewage treatment
    plant, and porewater extracted from
    sediment of a polluted river. We used
    expression of vitillogen (VTG) from
    cultured primary hepatocytes from
    Japanese medaka, Oryzias latips, as the
    biomarker. Results show that, except
    porewater could not have significant
    outcome due to contamination of the
    culture cells, other water samples tested
    led to expression of VTG in exposed
    hepatocytes, and the productions was
    time-dependent.
    關聯: 計畫編號：CNEM9301
    显示于类别:[環境資源管理系(所)] 校內計畫

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