數種植物對細胞發炎傷害之影響─子計劃2 ：芝麻種皮對脂多醣引發鼠肝細胞Inos及COX-2蛋白表現的影響

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Title:	數種植物對細胞發炎傷害之影響─子計劃2 ：芝麻種皮對脂多醣引發鼠肝細胞Inos及COX-2蛋白表現的影響
Authors:	晏文潔
Contributors:	食品科技系
Keywords:	芝麻種皮低密度脂蛋白氧化一氧化氮合成酵素 ethanolic extracts of sesame coat low-density lipoprotein oxidation inducible nitric oxide synthase
Date:	2004
Issue Date:	2008-06-19 09:58:42 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學食品科技系
Abstract:	本研究初步探討芝麻種皮對低密度脂蛋白氧化及巨噬細胞一氧化氮合成酵素( inducible nitric oxide synthase; iNOS) 表現之影響。芝麻種皮在0.1~0.8 mg/ml可以有效減少低密度脂蛋白氧化。另外，芝麻種皮不但可以捕捉一氧化氮自由基，也可以降低脂多醣(Lipopolysaccharide; LPS)對巨噬細胞株RAW 264.7誘發iNOS及COX-2蛋白表現。另外，芝麻種皮也可以有效減少iNOS及COX-2 mRNA表現。 The effects of ethanolic extracts of sesame coat on low-density lipoprotein oxidation and macrophage inducible nitric oxide synthase (iNOS) expression were investigated. At 0.1~0.8 mg/ml, the ethanolic extracts of sesame coat showed a protective role on low-density lipoprotein oxidation. Furthermore, the ethanolic extracts of sesame coat not only scavenged nitric oxide but also inhibited iNOS and cyclooxygenase-2 protein expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. On the other hand, the ethanolic extracts of sesame coat also displayed obviously inhibitiory effects on iNOS and cyclooxygenase-2 mRNA expression.
Relation:	計畫編號：CNFS9301_2
Appears in Collections:	[Dept. of Food Science & Technology] Chna Project

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