Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/906
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    Title: 數種植物對細胞發炎傷害之影響─子計劃1 :咖啡渣萃取物對含氮自由基造成蛋白硝化的影響
    Authors: 杜平悳
    Contributors: 食品科技系
    Keywords: 咖啡渣萃取物
    低密度脂蛋白氧化
    蛋白硝化
    water extracts of roasted coffee residue
    low-density lipoprotein
    protein nitration
    Date: 2004
    Issue Date: 2008-06-19 09:58:42 (UTC+8)
    Publisher: 台南縣:嘉南藥理科技大學食品科技系
    Abstract: 本研究探討咖啡渣萃取物(WERCR) 對低密度脂蛋白氧化及對peroxynitrite引發SVEC內皮細胞株蛋白硝化作用之影響。咖啡渣萃取物在0.02 - 0.1 mg/ml可以有效減少低密度脂蛋白氧化。另外,咖啡渣萃取物不但可以捕捉一氧化氮自由基,也可以有效捕捉超氧自由基。雖然咖啡渣萃取物無法減少脂多醣(Lipopolysaccharide; LPS)對巨噬細胞株RAW 264.7誘發iNOS及COX-2蛋白表現,但是可以有效減少peroxynitrite對內皮細胞進行蛋白硝化作用,此結果與與彼等捕捉一氧化氮與超氧陰離子有關係。
    The effects of water extracts of roasted coffee residue (WERER) on low-density lipoprotein oxidation and peroxynitrite-induced protein nitration in SVEC endothelium cells were investigated. At 0.02~0.1 mg/ml, WERER showed a protective role on low-density lipoprotein oxidation. Furthermore,WERER not only directly scavenged nitric oxide but also scavenged superoxide. WERER could not affect iNOS and cyclooxygenase-2 protein expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. On the other hand, WERER displayed obviously inhibition effects on peroxynitrite-induced protein nitration in endothelium cells.
    Relation: 計畫編號:CNFS9301_1
    Appears in Collections:[Dept. of Food Science & Technology] Chna Project

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