爵牀與早田氏爵牀成分及抗血小板凝集活性成分之研究

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標題:	爵牀與早田氏爵牀成分及抗血小板凝集活性成分之研究 Studies on the constituents and antiplatelet constituents of Justicia procumbens and Justicia procumbens var.
作者:	鐘婉榕 Wan-jung Chung
貢獻者:	林忠男楊竹茂嘉南藥理科技大學：生物科技研究所
關鍵字:	爵牀科早田氏爵牀爵牀血小板凝集成分木質素 lignan glycoside constituents Acanthaceae Justicia procumbens L. var. hayatai Justicia procumbens L. platelet aggregation
日期:	2005
上傳時間:	2008-10-31 16:15:45 (UTC+8)
摘要:	由爵牀科(Acanthaceae) 之早田氏爵牀 [Justicia procumbens L. var.] 植物的全草，分離得到7個已知化合物：β-sitosterol (1), diphyllin（2）, justicidin C (3), justicidin B (4), ciliatoside A （5）, justicidin D (6), procumphthalide A (7)另外由爵牀 (Justicia procumbens L.) 植物的全草，分離得到1個新的化合物，命名為procumbenoside C (8). 將其中justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7)進行對人類血漿中血小板之凝集抑制研究。初步結果顯示，化合物justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7) 對由epinephrine所誘發之血小板凝集作用有顯著的抑制作用。 Seven known compounds, β-sitosterol (1), diphyllin (2), justicidin C (3), justicidin B (4), ciliatoside A (5), justicidin D (6), and procumphthalide A (7) have been isolated from the whole plant of Justicia procumbens L.var., In addition, a new lignan glycoside, procumbenoside C (8), has been isolated from the whole plant of J. procumbents L. (Acanthaceae). Compounds justicidin C (3), justicidin B (4), justicidin D (6) and procumphthalide A (7) were screened for the inhibitory effect, on epinephrine-induced platelet aggregation in human platelet-rich plasma (PRP). The results indicated that justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7) significantly inhibited the platelet aggregation induced by epinephrine in human PRP.
關聯:	校內校外均不公開
顯示於類別:	[生物科技系(所)] 博碩士論文

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