Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/6166
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/6166


    Title: 爵牀與早田氏爵牀成分及抗血小板凝集活性成分之研究
    Studies on the constituents and antiplatelet constituents of Justicia procumbens and Justicia procumbens var.
    Authors: 鐘婉榕
    Wan-jung Chung
    Contributors: 林忠男
    楊竹茂
    嘉南藥理科技大學：生物科技研究所
    Keywords: 爵牀科
    早田氏爵牀
    爵牀
    血小板凝集
    成分
    木質素
    lignan glycoside
    constituents
    Acanthaceae
    Justicia procumbens L. var. hayatai
    Justicia procumbens L.
    platelet aggregation
    Date: 2005
    Issue Date: 2008-10-31 16:15:45 (UTC+8)
    Abstract: 由爵牀科(Acanthaceae) 之早田氏爵牀 [Justicia procumbens L. var.] 植物的全草，分離得到7個已知化合物：β-sitosterol (1), diphyllin（2）, justicidin C (3), justicidin B (4), ciliatoside A （5）, justicidin D (6), procumphthalide A (7)另外由爵牀 (Justicia procumbens L.) 植物的全草，分離得到1個新的化合物，命名為procumbenoside C (8).
    將其中justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7)進行對人類血漿中血小板之凝集抑制研究。
    初步結果顯示，化合物justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7) 對由epinephrine所誘發之血小板凝集作用有顯著的抑制作用。
    Seven known compounds, β-sitosterol (1), diphyllin (2), justicidin C (3), justicidin B (4), ciliatoside A (5), justicidin D (6), and procumphthalide A (7) have been isolated from the whole plant of Justicia procumbens L.var., In addition, a new lignan glycoside, procumbenoside C (8), has been isolated from the whole plant of J. procumbents L. (Acanthaceae).
    Compounds justicidin C (3), justicidin B (4), justicidin D (6) and procumphthalide A (7) were screened for the inhibitory effect, on epinephrine-induced platelet aggregation in human platelet-rich plasma (PRP). The results indicated that justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7) significantly inhibited the platelet aggregation induced by epinephrine in human PRP.
    Relation: 校內校外均不公開
    Appears in Collections:[Dept. of Biotechnology (including master's program)] Dissertations and Theses

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