| 摘要: | 由爵牀科(Acanthaceae) 之早田氏爵牀 [Justicia procumbens L. var.] 植物的全草，分離得到7個已知化合物：β-sitosterol (1), diphyllin（2）, justicidin C (3), justicidin B (4), ciliatoside A （5）, justicidin D (6), procumphthalide A (7)另外由爵牀 (Justicia procumbens L.) 植物的全草，分離得到1個新的化合物，命名為procumbenoside C (8).
將其中justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7)進行對人類血漿中血小板之凝集抑制研究。
初步結果顯示，化合物justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7) 對由epinephrine所誘發之血小板凝集作用有顯著的抑制作用。
Seven known compounds, β-sitosterol (1), diphyllin (2), justicidin C (3), justicidin B (4), ciliatoside A (5), justicidin D (6), and procumphthalide A (7) have been isolated from the whole plant of Justicia procumbens L.var., In addition, a new lignan glycoside, procumbenoside C (8), has been isolated from the whole plant of J. procumbents L. (Acanthaceae).
Compounds justicidin C (3), justicidin B (4), justicidin D (6) and procumphthalide A (7) were screened for the inhibitory effect, on epinephrine-induced platelet aggregation in human platelet-rich plasma (PRP). The results indicated that justicidin C (3), justicidin B (4), justicidin D (6), procumphthalide A (7) significantly inhibited the platelet aggregation induced by epinephrine in human PRP. |
