含不同分子量PEO之新聚氨基甲酸酯聚合體之合成及其液晶複合膜之製備與血液相容性之研究

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Title:	含不同分子量PEO之新聚氨基甲酸酯聚合體之合成及其液晶複合膜之製備與血液相容性之研究
Authors:	蕭明達
Contributors:	醫藥化學系
Keywords:	液晶複合膜血液相容性質 liquid crystal composite membranes blood compatibility
Date:	2005
Issue Date:	2008-05-26 14:15:56 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學醫藥化學系
Abstract:	我們自行合成兩種新型聚胺基甲酸酯材料(PUMA,PUMB)。兩者差異在於導入親水性結構(PEG)的有無。實驗中使用光聚合合成法製備此兩種型式的液晶/PU 複合膜(PUMA型,PUMB型)。為了評估複合膜與血液相容性質之關係，我們以SEM觀察血小板在複合膜表面吸附情況、血液凝塊的變化量及溶血率性質，此三種測試來做為評估實驗。實驗結果發現PU材料結構，導入液晶或是親水性基團會有利於改善材料本身之血液相容性質。 Two polyurethanes, PUMA and PUMB, were synthesized in this study. PUMB containing Polyethylene glycol(PEG，MW=200) polar group in the structure. Using photo-polymerization method, we prepared two series of Polyurethane/liquid crystal composite membranes based on two kinds of polymers（PUMA,PUMB）. In order to evaluate the blood compatibility of these membranes, we did a series of test, such as SEM observation of the platelet adhesion to membrane surface, blood clotting and haemolysis ratio. The results showed that the content of liquid crystal or PEG polar group in composite membrane, appear to be beneficial in improving the blood compatibility.
Relation:	計畫編號 : CNAC9403
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Chna Project

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