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| 標題: | In Vitro Assessment of the Antioxidant and Anticancer Properties of Flammulina velutipes Stipe Extracts |
| 作者: | Chen, Chien-Chin
Tang, Chung-Tao
Lai, Chao-Yang
Han, Chien-Kuo
Cheng, Yu-Hsuan
Lin, Yu-Feng
Lin, Cheng-Ting
Huang, Yuan-Li |
| 貢獻者: | Chia Yi Christian Hosp, Dept Pathol, Ditmanson Med Fdn
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
I Shou Univ, Sch Med Int Students, Coll Med
Asia Univ, Dept Med Lab Sci & Biotechnol
Asia Univ, Food Nutr & Hlth Biotechnol
Asia Univ, Nursing
Asia Univ, Optometry
Asia Univ, Edible & Med Mushrooms Res Ctr, Taichung, Taiwan;[Huang, Yuan-Li
China Med Univ Hosp, Dept Med Res |
| 關鍵字: | Flammulina velutipes
antioxidant
anticancer
prostate cancer |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:05:43 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | Background/Aim: Flammulina velutipes (FV), also known as the golden needle mushroom, is an edible and medicinal fungus that contains bioactive substances regulating various physiological functions. While the fruiting bodies of FV are commonly consumed, their stipes are often discarded despite containing polysaccharides. In this study, the biological functions of FV stipes (FV-S) were investigated to reduce waste and pollution while increasing their value. Materials and Methods: The antioxidant activity of FV was evaluated using three methods: the DPPH radical-scavenging capacity assay, ferrous ion chelating assay, and reducing power analysis. The anti-cancer potential was assessed through MTT viability and immunoblotting analyses. Results: Results showed that FV- S had higher polysaccharide and total phenolic contents and greater antioxidant abilities, particularly in ethanolic extracts. FV-S also exhibited significant anticancer properties, specifically in hot water extracts with high polysaccharide contents, and suppressed prostate cancer cell viability by inhibiting androgen receptor and PCa-specific antigen mRNA expression while inducing caspase-3/7 activation. Conclusion: FV-S is rich in bioactive components, possesses higher antioxidant and anticancer abilities, and has potential as an anticancer agent, which could enhance the value of FV. |
| 關聯: | Anticancer Research, v.43, n.7, pp.3057-3067 |
| 顯示於類別: | [行政單位] 456
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