In Vitro Assessment of the Antioxidant and Anticancer Properties of Flammulina velutipes Stipe Extracts

doi:10.21873/anticanres.16477

Chia Nan University of Pharmacy & Science Institutional Repository > 行政單位 > 456 > Item 310902800/34924

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標題:	In Vitro Assessment of the Antioxidant and Anticancer Properties of Flammulina velutipes Stipe Extracts
作者:	Chen, Chien-Chin Tang, Chung-Tao Lai, Chao-Yang Han, Chien-Kuo Cheng, Yu-Hsuan Lin, Yu-Feng Lin, Cheng-Ting Huang, Yuan-Li
貢獻者:	Chia Yi Christian Hosp, Dept Pathol, Ditmanson Med Fdn Chia Nan Univ Pharm & Sci, Dept Cosmet Sci I Shou Univ, Sch Med Int Students, Coll Med Asia Univ, Dept Med Lab Sci & Biotechnol Asia Univ, Food Nutr & Hlth Biotechnol Asia Univ, Nursing Asia Univ, Optometry Asia Univ, Edible & Med Mushrooms Res Ctr, Taichung, Taiwan;[Huang, Yuan-Li China Med Univ Hosp, Dept Med Res
關鍵字:	Flammulina velutipes antioxidant anticancer prostate cancer
日期:	2023
上傳時間:	2024-12-25 11:05:43 (UTC+8)
出版者:	INT INST ANTICANCER RESEARCH
摘要:	Background/Aim: Flammulina velutipes (FV), also known as the golden needle mushroom, is an edible and medicinal fungus that contains bioactive substances regulating various physiological functions. While the fruiting bodies of FV are commonly consumed, their stipes are often discarded despite containing polysaccharides. In this study, the biological functions of FV stipes (FV-S) were investigated to reduce waste and pollution while increasing their value. Materials and Methods: The antioxidant activity of FV was evaluated using three methods: the DPPH radical-scavenging capacity assay, ferrous ion chelating assay, and reducing power analysis. The anti-cancer potential was assessed through MTT viability and immunoblotting analyses. Results: Results showed that FV- S had higher polysaccharide and total phenolic contents and greater antioxidant abilities, particularly in ethanolic extracts. FV-S also exhibited significant anticancer properties, specifically in hot water extracts with high polysaccharide contents, and suppressed prostate cancer cell viability by inhibiting androgen receptor and PCa-specific antigen mRNA expression while inducing caspase-3/7 activation. Conclusion: FV-S is rich in bioactive components, possesses higher antioxidant and anticancer abilities, and has potential as an anticancer agent, which could enhance the value of FV.
關聯:	Anticancer Research, v.43, n.7, pp.3057-3067
显示于类别:	[行政單位] 456

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