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https://ir.cnu.edu.tw/handle/310902800/34923
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| 標題: | Thiamet G as a Potential Treatment for Polycystic Kidney Disease |
| 作者: | Su, Wen-Cheng
Hung, Chi-Feng
Wang, Yi-Chieh
Peng, Hubert
Huang, Wen-Hung
Lo, Yi-Lun
Lo, Yun-Hwa
Chen, Yi-Cheng
Su, Hsin-Hui
Chen, Yung-Liang |
| 貢獻者: | Yuan Pei Univ Med Technol, Dept Med Lab Sci & Biotechnol
Chia yi Christian Hosp, Ditmanson Med Fdn, Dept Urol
Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol
Acad Sinica, Inst Mol Biol
Natl Yang Ming Chiao Tung Univ, Coll Med, Inst Pharmacol
Kaohsiung Med Univ, Coll Life Sci, Dept Med & Appl Chem
Natl Pingtung Univ Sci & Technol, Dept Vet Med
Chia Nan Univ Pharm & Sci, Dept Pharm
Yuan Pei Univ Sci & Technol, Dept Med Lab Sci & Biotechnol
Chia Nan Univ Pharm & Sci, Dept Pharm |
| 關鍵字: | Autosomal dominant polycystic kidney disease
ADPKD
O-linked N-acetylglucosamine
Thiamet G |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:05:42 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | Background/Aim: Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder primarily caused by mutations in Pkd1 (PC1), which account for the majority of ADPKD cases. These mutations contribute to the formation of cysts in the kidneys and other organs, ultimately leading to renal failure. Unfortunately, there are currently no available preventive treatments for this disease. Materials and Methods: In this study, we utilized Pkd1-knockdown mice and cells to investigate the potential involvement of O-GlcNAcylation in the progression of PKD. Additionally, we examined the effects of thiamet G, an inhibitor of O-GlcNAcase (OGA), on PKD mice. Results: Our findings indicate that both O-GlcNAcylation and OGT (O-GlcNAc transferase) were downregulated in the renal tissues of Pkd1-silenced mice. Furthermore, OGlcNAcylation was shown to regulate the stability and function of the C-terminal cytoplasmic tail (CTT) of PC1. Treatment of PKD mice with thiamet G resulted in a reduction of renal cytogenesis in these animals. Conclusion: These results highlight the unique role of O-GlcNAcylation in the development of cyst formation in PKD and propose it as a potential therapeutic target for the treatment of PKD. |
| 關聯: | In Vivo, v.37, n.6, pp.2524-2532 |
| 顯示於類別: | [行政單位] 456
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