Thiamet G as a Potential Treatment for Polycystic Kidney Disease

doi:10.21873/invivo.13360

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34923

Title:	Thiamet G as a Potential Treatment for Polycystic Kidney Disease
Authors:	Su, Wen-Cheng Hung, Chi-Feng Wang, Yi-Chieh Peng, Hubert Huang, Wen-Hung Lo, Yi-Lun Lo, Yun-Hwa Chen, Yi-Cheng Su, Hsin-Hui Chen, Yung-Liang
Contributors:	Yuan Pei Univ Med Technol, Dept Med Lab Sci & Biotechnol Chia yi Christian Hosp, Ditmanson Med Fdn, Dept Urol Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol Acad Sinica, Inst Mol Biol Natl Yang Ming Chiao Tung Univ, Coll Med, Inst Pharmacol Kaohsiung Med Univ, Coll Life Sci, Dept Med & Appl Chem Natl Pingtung Univ Sci & Technol, Dept Vet Med Chia Nan Univ Pharm & Sci, Dept Pharm Yuan Pei Univ Sci & Technol, Dept Med Lab Sci & Biotechnol Chia Nan Univ Pharm & Sci, Dept Pharm
Keywords:	Autosomal dominant polycystic kidney disease ADPKD O-linked N-acetylglucosamine Thiamet G
Date:	2023
Issue Date:	2024-12-25 11:05:42 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	Background/Aim: Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder primarily caused by mutations in Pkd1 (PC1), which account for the majority of ADPKD cases. These mutations contribute to the formation of cysts in the kidneys and other organs, ultimately leading to renal failure. Unfortunately, there are currently no available preventive treatments for this disease. Materials and Methods: In this study, we utilized Pkd1-knockdown mice and cells to investigate the potential involvement of O-GlcNAcylation in the progression of PKD. Additionally, we examined the effects of thiamet G, an inhibitor of O-GlcNAcase (OGA), on PKD mice. Results: Our findings indicate that both O-GlcNAcylation and OGT (O-GlcNAc transferase) were downregulated in the renal tissues of Pkd1-silenced mice. Furthermore, OGlcNAcylation was shown to regulate the stability and function of the C-terminal cytoplasmic tail (CTT) of PC1. Treatment of PKD mice with thiamet G resulted in a reduction of renal cytogenesis in these animals. Conclusion: These results highlight the unique role of O-GlcNAcylation in the development of cyst formation in PKD and propose it as a potential therapeutic target for the treatment of PKD.
Relation:	In Vivo, v.37, n.6, pp.2524-2532
Appears in Collections:	[Offices] 456

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