Plasma Glial Cell-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels Were Not Correlated with the Severity of Age-Related Hearing Impairment in Humans

doi:10.1021/acsomega.3c08354

Chia Nan University of Pharmacy & Science Institutional Repository > 行政單位 > 456 > Item 310902800/34918

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34918

標題:	Plasma Glial Cell-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels Were Not Correlated with the Severity of Age-Related Hearing Impairment in Humans
作者:	Hsieh, Pei-Shan Hwang, Shang-Rung Hwang, Sheng-Wei Hwang, Juen-Haur
貢獻者:	Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Pharm Natl Yang Ming Chiao Tung Univ, Sch Med Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Otolaryngol Head & Neck Surg Tzu Chi Univ, Sch Med China Med Univ, China Med Univ Hosp, Dept Med Res
關鍵字:	EXPRESSION ASSOCIATION PROTECTION
日期:	2023
上傳時間:	2024-12-25 11:05:38 (UTC+8)
出版者:	AMER CHEMICAL SOC
摘要:	The relationship between plasma glial cell-derived neurotrophic factor (GDNF) or insulin-like growth factor-1 (IGF-1) levels and age-related hearing impairment (ARHI) has not been reported in humans. By cross-sectional design, 268 subjects older than 33, with normal cognitive function and normal or symmetric sensorineural hearing loss, were selected randomly. Multivariate linear regression analysis was performed to test the impact of the plasma GDNF or IGF-1 level on the pure tone threshold of low frequencies (PTA-low) and high frequencies (PTA-high), respectively. Results showed that plasma GDNF and IGF-1 levels decreased with age without statistical significance. Multivariate linear regression analysis showed that GDNF or IGF-1 levels were not significantly correlated with PTA-low or PTA-high after adjusting age, gender, body mass index, systemic diseases, habits, and noise exposure. In conclusion, plasma GDNF or IGF-1 levels were not associated with the severity of ARHI in humans. However, these findings did not support the roles of GDNF or IGF-1 genotypes on hearing.
關聯:	Acs Omega, v.9, n.1, pp.1757-1761
显示于类别:	[行政單位] 456

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	7	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....