Plasma Glial Cell-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels Were Not Correlated with the Severity of Age-Related Hearing Impairment in Humans

doi:10.1021/acsomega.3c08354

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/34918

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34918

Title:	Plasma Glial Cell-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels Were Not Correlated with the Severity of Age-Related Hearing Impairment in Humans
Authors:	Hsieh, Pei-Shan Hwang, Shang-Rung Hwang, Sheng-Wei Hwang, Juen-Haur
Contributors:	Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Pharm Natl Yang Ming Chiao Tung Univ, Sch Med Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Otolaryngol Head & Neck Surg Tzu Chi Univ, Sch Med China Med Univ, China Med Univ Hosp, Dept Med Res
Keywords:	EXPRESSION ASSOCIATION PROTECTION
Date:	2023
Issue Date:	2024-12-25 11:05:38 (UTC+8)
Publisher:	AMER CHEMICAL SOC
Abstract:	The relationship between plasma glial cell-derived neurotrophic factor (GDNF) or insulin-like growth factor-1 (IGF-1) levels and age-related hearing impairment (ARHI) has not been reported in humans. By cross-sectional design, 268 subjects older than 33, with normal cognitive function and normal or symmetric sensorineural hearing loss, were selected randomly. Multivariate linear regression analysis was performed to test the impact of the plasma GDNF or IGF-1 level on the pure tone threshold of low frequencies (PTA-low) and high frequencies (PTA-high), respectively. Results showed that plasma GDNF and IGF-1 levels decreased with age without statistical significance. Multivariate linear regression analysis showed that GDNF or IGF-1 levels were not significantly correlated with PTA-low or PTA-high after adjusting age, gender, body mass index, systemic diseases, habits, and noise exposure. In conclusion, plasma GDNF or IGF-1 levels were not associated with the severity of ARHI in humans. However, these findings did not support the roles of GDNF or IGF-1 genotypes on hearing.
Relation:	Acs Omega, v.9, n.1, pp.1757-1761
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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