Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34918
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34918


    题名: Plasma Glial Cell-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels Were Not Correlated with the Severity of Age-Related Hearing Impairment in Humans
    作者: Hsieh, Pei-Shan
    Hwang, Shang-Rung
    Hwang, Sheng-Wei
    Hwang, Juen-Haur
    贡献者: Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Natl Yang Ming Chiao Tung Univ, Sch Med
    Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Otolaryngol Head & Neck Surg
    Tzu Chi Univ, Sch Med
    China Med Univ, China Med Univ Hosp, Dept Med Res
    关键词: EXPRESSION
    ASSOCIATION
    PROTECTION
    日期: 2023
    上传时间: 2024-12-25 11:05:38 (UTC+8)
    出版者: AMER CHEMICAL SOC
    摘要: The relationship between plasma glial cell-derived neurotrophic factor (GDNF) or insulin-like growth factor-1 (IGF-1) levels and age-related hearing impairment (ARHI) has not been reported in humans. By cross-sectional design, 268 subjects older than 33, with normal cognitive function and normal or symmetric sensorineural hearing loss, were selected randomly. Multivariate linear regression analysis was performed to test the impact of the plasma GDNF or IGF-1 level on the pure tone threshold of low frequencies (PTA-low) and high frequencies (PTA-high), respectively. Results showed that plasma GDNF and IGF-1 levels decreased with age without statistical significance. Multivariate linear regression analysis showed that GDNF or IGF-1 levels were not significantly correlated with PTA-low or PTA-high after adjusting age, gender, body mass index, systemic diseases, habits, and noise exposure. In conclusion, plasma GDNF or IGF-1 levels were not associated with the severity of ARHI in humans. However, these findings did not support the roles of GDNF or IGF-1 genotypes on hearing.
    關聯: Acs Omega, v.9, n.1, pp.1757-1761
    显示于类别:[Dept. of Pharmacy] Periodical Articles

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