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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34913


    標題: Artesunate Exhibits Synergy With Cisplatin and Cytotoxicity for Upper Tract and Bladder Urothelial Carcinoma Cells
    作者: Chen, San-Yuan
    Chao, Chun-Nun
    Huang, Hsin-Yi
    Zhao, Pei-Wen
    Fang, Chiung-Yao
    貢獻者: Ditmanson Med Fdn Chiayi Christian Hosp, Dept Chinese Med
    Chia Nan Univ Pharm & Sci, Dept Sports Management
    Ditmanson Med Fdn Chiayi Christian Hosp, Dept Paediat
    Asia Univ, Dept Biotechnol
    Ditmanson Med Fdn Chiayi Christian Hosp, Dept Med Res, 539 Chung Hsiao Rd, Chiayi 600, Taiwan
    關鍵字: Artesunate
    urothelial carcinoma
    ROS
    synergy
    cisplatin
    日期: 2023
    上傳時間: 2024-12-25 11:05:33 (UTC+8)
    出版者: INT INST ANTICANCER RESEARCH
    摘要: Background/Aim: Urothelial carcinoma (UC) may arise from the urothelium of the upper tract and the bladder. Cisplatin-based therapy remains the gold standard for UC treatment. The poor 5-year survival rate of UC patients creates an urgent need to develop new drugs for advanced UC therapy. Artesunate (ART), a traditional Chinese medicine for treating malaria, is a potential anticancer agent, but its antigrowth effects on upper tract and bladder UC have not been investigated. Materials and Methods: The antigrowth effect of ART in HT 1376 (bladder UC cells) and BFTC 909 [upper tract urothelial carcinoma (UTUC) cells] was determined by the CCK-8 assay. Flow cytometric analysis was used to evaluate the cell cycle distribution and apoptosis. The cell cycle, apoptosis, and autophagy-related protein expression were analyzed by western blotting. The efficacy of combination treatment with cisplatin was determined by the Calcusyn software. Results: ART induced HT 1376 and BFTC 909 cell death in a concentration- and time-dependent manner, inducing G2/M cell-cycle arrest. ART induced apoptosis and redox imbalance in HT 1376 and BFTC 909 cells. Application of the reactive oxygen species death in ART-treated UC cells. BFTC 909 cells show a better response after ART treatment. Conclusion: ART may be a candidate drug for treating UTUC and bladder UC while increasing the therapeutic effect of cisplatin.
    關聯: Anticancer Research, v.43, n.3, pp.1175-1184
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