Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection

doi:10.1007/s00394-023-03298-3

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34902

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34902

Title:	Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection
Authors:	Wu, Jheng-Yan Liu, Mei-Yuan Hsu, Wan-Hsuan Tsai, Ya-Wen Liu, Ting-Hui Huang, Po-Yu Chuang, Min-Hsiang Chin, Szu-En Lai, Chih-Cheng
Contributors:	Chi Mei Med Ctr, Dept Nutr Kaohsiung Med Univ, Grad Inst Med, Coll Med Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth Chang Jung Christian Univ, Dept Nutr & Hlth Sci Chung Hwa Univ Med Technol, Dept Food Nutr Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Gen Med Chi Mei Med Ctr, Ctr Integrat Med Chi Mei Med Ctr, Dept Psychiat Chi Mei Med Ctr, Dept Internal Med Chang Gung Mem Hosp Chiayi, Dept Surg Chi Mei Med Ctr, Div Hosp Med, Dept Internal Med Natl Sun Yat Sen Univ, Coll Med, Sch Med
Keywords:	Post-COVID-19 condition Long COVID SARS-CoV-2 Vitamin D Hospitalization Mortality
Date:	2024
Issue Date:	2024-12-25 11:05:21 (UTC+8)
Publisher:	SPRINGER HEIDELBERG
Abstract:	Objectives This study aimed to investigate the association between vitamin D deficiency (VDD) and post-acute outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Methods This retrospective study used the TriNetX research network to identify COVID-19 patients between January 1 and November 30, 2022. Patients were matched using propensity score matching (PSM) and divided into VDD (< 20 ng/mL) and control (>= 20 ng/mL) groups. The primary outcome was a composite of post-COVID-19 condition (identified by ICD-10 code), all-cause emergency department (ED) visits, hospitalization, and death during the follow-up period (90-180 days) after the diagnosis of COVID-19.Results From an initial recruitment of 42,674 non-hospitalized patients with COVID-19 and known 25(OH)D status, a VDD group of 8300 was identified and propensity matched with 8300 controls. During the follow-up period, the VDD group had a higher risk of the primary outcome than did the control group [hazard ratio (HR) = 1.122; 95% confidence interval (CI) = 1.041-1.210]. The VDD group also had a higher risk of all-cause ED visits (HR = 1.114; 95% CI = 1.012-1.226), all-cause hospitalization (HR = 1.230; 95% CI = 1.105-1.369), and all-cause death (HR = 1.748; 95% CI = 1.047-2.290) but not post-COVID-19 condition (HR = 0.980; 95% CI = 0.630-1.523), individually.Conclusion Among the COVID-19 patients, VDD might be associated with a higher risk of all-cause ED visits, hospitalization, and death during the post-acute phase.
Relation:	European Journal of Nutrition, v.63, n.2, pp.613-622
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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