Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection

doi:10.1007/s00394-023-03298-3

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/34902

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標題:	Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection
作者:	Wu, Jheng-Yan Liu, Mei-Yuan Hsu, Wan-Hsuan Tsai, Ya-Wen Liu, Ting-Hui Huang, Po-Yu Chuang, Min-Hsiang Chin, Szu-En Lai, Chih-Cheng
貢獻者:	Chi Mei Med Ctr, Dept Nutr Kaohsiung Med Univ, Grad Inst Med, Coll Med Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth Chang Jung Christian Univ, Dept Nutr & Hlth Sci Chung Hwa Univ Med Technol, Dept Food Nutr Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Gen Med Chi Mei Med Ctr, Ctr Integrat Med Chi Mei Med Ctr, Dept Psychiat Chi Mei Med Ctr, Dept Internal Med Chang Gung Mem Hosp Chiayi, Dept Surg Chi Mei Med Ctr, Div Hosp Med, Dept Internal Med Natl Sun Yat Sen Univ, Coll Med, Sch Med
關鍵字:	Post-COVID-19 condition Long COVID SARS-CoV-2 Vitamin D Hospitalization Mortality
日期:	2024
上傳時間:	2024-12-25 11:05:21 (UTC+8)
出版者:	SPRINGER HEIDELBERG
摘要:	Objectives This study aimed to investigate the association between vitamin D deficiency (VDD) and post-acute outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Methods This retrospective study used the TriNetX research network to identify COVID-19 patients between January 1 and November 30, 2022. Patients were matched using propensity score matching (PSM) and divided into VDD (< 20 ng/mL) and control (>= 20 ng/mL) groups. The primary outcome was a composite of post-COVID-19 condition (identified by ICD-10 code), all-cause emergency department (ED) visits, hospitalization, and death during the follow-up period (90-180 days) after the diagnosis of COVID-19.Results From an initial recruitment of 42,674 non-hospitalized patients with COVID-19 and known 25(OH)D status, a VDD group of 8300 was identified and propensity matched with 8300 controls. During the follow-up period, the VDD group had a higher risk of the primary outcome than did the control group [hazard ratio (HR) = 1.122; 95% confidence interval (CI) = 1.041-1.210]. The VDD group also had a higher risk of all-cause ED visits (HR = 1.114; 95% CI = 1.012-1.226), all-cause hospitalization (HR = 1.230; 95% CI = 1.105-1.369), and all-cause death (HR = 1.748; 95% CI = 1.047-2.290) but not post-COVID-19 condition (HR = 0.980; 95% CI = 0.630-1.523), individually.Conclusion Among the COVID-19 patients, VDD might be associated with a higher risk of all-cause ED visits, hospitalization, and death during the post-acute phase.
關聯:	European Journal of Nutrition, v.63, n.2, pp.613-622
顯示於類別:	[保健營養系(所) ] 期刊論文

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