Association between soluble a-klotho and mortality risk in middle-aged and older adults

doi:10.3389/fendo.2023.1246590

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/34878

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34878

標題:	Association between soluble a-klotho and mortality risk in middle-aged and older adults
作者:	Chuang, Min-Hsiang Wang, Hung-Wei Huang, Yun-Ting Jiang, Ming-Yan
貢獻者:	Chi Mei Med Ctr, Dept Internal Med, Renal Div Chi Mei Hosp Chiali, Dept Internal Med, Renal Div Chia Nan Univ Pharm & Sci, Dept Pharm
關鍵字:	klotho aging all-cause mortality chronic kidney disease (CKD) hepatitis C virus (HCV)
日期:	2023
上傳時間:	2024-12-25 11:04:58 (UTC+8)
出版者:	FRONTIERS MEDIA SA
摘要:	IntroductionStudies on association of & alpha;-klotho levels with mortality risk in general population are relatively scarce and inconclusive. Therefore, we conducted a population-based cohort study to investigate the relationship between soluble & alpha;-klotho and all-cause mortality in a nationally representative sample of middle-aged and older adults in the United States (U.S.).MethodsThe study population was 2007-2016 National Health and Nutrition Examination Survey (NHANES) participants, totaling 13,583 adults aged 40-79 years. Participants were divided into 7 groups by septile of & alpha;-klotho levels. We linked the NHANES data to the National Death Index to determine participants' survival status. End of follow-up was participants' death date or December 31, 2019.ResultsWe observed that males, current smokers, older age, higher body mass index, and lower estimated glomerular filtration rate correlated to lower & alpha;-klotho levels, while hepatitis C virus infection correlated to higher & alpha;-klotho. The population mortality rate was 11.8 per 10,000 person-months (1,490 deaths); group 1 (the first septile) had higher mortality risk compared with group 2 through group 7. By weighted Cox regression with adjustment for potential confounders, we found that group 2 through group 6, but not group 7, were associated with 25% to 35% lower risk of all-cause mortality compared with group 1. When compared with group 4, we observed that both group 1 (HR: 1.46, 95% CI 1.13-1.88) and group 7 (HR: 1.38, 95% CI 1.09-1.74) were associated with higher mortality risk.ConclusionIn summary, among middle-aged and older U.S. adults, we observed a non-linear association between soluble & alpha;-klotho and all-cause mortality, with individuals at the two extremes at increased risk of death.
關聯:	Frontiers in Endocrinology, v.14, Article 1246590
显示于类别:	[保健營養系(所) ] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
fendo.2023.1246590.pdf		1688Kb	Adobe PDF	3	检视/开启
index.html		0Kb	HTML	5	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....