Association between soluble a-klotho and mortality risk in middle-aged and older adults

doi:10.3389/fendo.2023.1246590

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34878

Title:	Association between soluble a-klotho and mortality risk in middle-aged and older adults
Authors:	Chuang, Min-Hsiang Wang, Hung-Wei Huang, Yun-Ting Jiang, Ming-Yan
Contributors:	Chi Mei Med Ctr, Dept Internal Med, Renal Div Chi Mei Hosp Chiali, Dept Internal Med, Renal Div Chia Nan Univ Pharm & Sci, Dept Pharm
Keywords:	klotho aging all-cause mortality chronic kidney disease (CKD) hepatitis C virus (HCV)
Date:	2023
Issue Date:	2024-12-25 11:04:58 (UTC+8)
Publisher:	FRONTIERS MEDIA SA
Abstract:	IntroductionStudies on association of & alpha;-klotho levels with mortality risk in general population are relatively scarce and inconclusive. Therefore, we conducted a population-based cohort study to investigate the relationship between soluble & alpha;-klotho and all-cause mortality in a nationally representative sample of middle-aged and older adults in the United States (U.S.).MethodsThe study population was 2007-2016 National Health and Nutrition Examination Survey (NHANES) participants, totaling 13,583 adults aged 40-79 years. Participants were divided into 7 groups by septile of & alpha;-klotho levels. We linked the NHANES data to the National Death Index to determine participants' survival status. End of follow-up was participants' death date or December 31, 2019.ResultsWe observed that males, current smokers, older age, higher body mass index, and lower estimated glomerular filtration rate correlated to lower & alpha;-klotho levels, while hepatitis C virus infection correlated to higher & alpha;-klotho. The population mortality rate was 11.8 per 10,000 person-months (1,490 deaths); group 1 (the first septile) had higher mortality risk compared with group 2 through group 7. By weighted Cox regression with adjustment for potential confounders, we found that group 2 through group 6, but not group 7, were associated with 25% to 35% lower risk of all-cause mortality compared with group 1. When compared with group 4, we observed that both group 1 (HR: 1.46, 95% CI 1.13-1.88) and group 7 (HR: 1.38, 95% CI 1.09-1.74) were associated with higher mortality risk.ConclusionIn summary, among middle-aged and older U.S. adults, we observed a non-linear association between soluble & alpha;-klotho and all-cause mortality, with individuals at the two extremes at increased risk of death.
Relation:	Frontiers in Endocrinology, v.14, Article 1246590
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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