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| 標題: | In vitro activities of antimicrobial combinations against planktonic and biofilm forms of Stenotrophomonas maltophilia |
| 作者: | Su, Bo-An
Chen, Chi-Chung
Chen, Hung-Jui
Lai, Hsin-Yu
Tsai, Chia-Hung
Lai, Chih-Cheng
Tang, Hung-Jen
Chao, Chien-Ming |
| 貢獻者: | Chi Mei Med Ctr, Dept Internal Med, Div Infect Dis
Chia Nan Univ Pharm & Sci, Dept Pharm
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chang Jung Christian Univ, Dept Biosci Technol
Chi Mei Med Ctr, Div Hosp Med, Dept Internal Med
Natl Sun Yat Sen Univ, Coll Med, Sch Med
Chi Mei Med Ctr, Dept Med
Chi Mei Med Ctr, Dept Intens Care Med |
| 關鍵字: | Stenotrophomonas maltophilia
levofloxacin
fosfomycin
ceftazidime-avibactam
tigecycline |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:54 (UTC+8) |
| 出版者: | FRONTIERS MEDIA SA |
| 摘要: | ObjectivesTo investigate the in vitro activity of antibiotic combinations against Stenotrophomonas maltophilia isolates and their associated biofilms. MethodsThirty-two S. maltophilia clinical isolates with at least twenty-five different pulsotypes were tested. The antibacterial activity of various antibiotic combinations against seven randomly selected planktonic and biofilm-embedded S. maltophilia strains with strong biofilm formation was assessed using broth methods. Extraction of bacterial genomic DNA and PCR detection of antibiotic resistance and biofilm-related genes were also performed. ResultsThe susceptibility rates of levofloxacin (LVX), fosfomycin (FOS), tigecycline (TGC) and sulfamethoxazole-trimethoprim (SXT) against 32 S. maltophilia isolates were 56.3, 71.9, 71.9 and 90.6%, respectively. Twenty-eight isolates were detected with strong biofilm formation. Antibiotic combinations, including aztreonam-clavulanic (ATM-CLA) with LVX, ceftazidime-avibactam (CZA) with LVX and SXT with TGC, exhibited potent inhibitory activity against these isolates with strong biofilm formation. The antibiotic resistance phenotype might not be fully caused by the common antibiotic-resistance or biofilm-formation gene. ConclusionS. maltophilia remained resistant to most antibiotics, including LVX and & beta;-lactam/& beta;-lactamases; however, TGC, FOS and SXT still exhibited potent activity. Although all tested S. maltophilia isolates exhibited moderate-to-strong biofilm formation, combination therapies, especially ATM-CLA with LVX, CZA with LVX and SXT with TGC, exhibited a higher inhibitory activity for these isolates. |
| 關聯: | Frontiers in Microbiology, v.14, Article 1186669 |
| 顯示於類別: | [藥學系(所)] 期刊論文
[保健營養系(所) ] 期刊論文
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