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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34873


    標題: In vitro activities of antimicrobial combinations against planktonic and biofilm forms of Stenotrophomonas maltophilia
    作者: Su, Bo-An
    Chen, Chi-Chung
    Chen, Hung-Jui
    Lai, Hsin-Yu
    Tsai, Chia-Hung
    Lai, Chih-Cheng
    Tang, Hung-Jen
    Chao, Chien-Ming
    貢獻者: Chi Mei Med Ctr, Dept Internal Med, Div Infect Dis
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chang Jung Christian Univ, Dept Biosci Technol
    Chi Mei Med Ctr, Div Hosp Med, Dept Internal Med
    Natl Sun Yat Sen Univ, Coll Med, Sch Med
    Chi Mei Med Ctr, Dept Med
    Chi Mei Med Ctr, Dept Intens Care Med
    關鍵字: Stenotrophomonas maltophilia
    levofloxacin
    fosfomycin
    ceftazidime-avibactam
    tigecycline
    日期: 2023
    上傳時間: 2024-12-25 11:04:54 (UTC+8)
    出版者: FRONTIERS MEDIA SA
    摘要: ObjectivesTo investigate the in vitro activity of antibiotic combinations against Stenotrophomonas maltophilia isolates and their associated biofilms. MethodsThirty-two S. maltophilia clinical isolates with at least twenty-five different pulsotypes were tested. The antibacterial activity of various antibiotic combinations against seven randomly selected planktonic and biofilm-embedded S. maltophilia strains with strong biofilm formation was assessed using broth methods. Extraction of bacterial genomic DNA and PCR detection of antibiotic resistance and biofilm-related genes were also performed. ResultsThe susceptibility rates of levofloxacin (LVX), fosfomycin (FOS), tigecycline (TGC) and sulfamethoxazole-trimethoprim (SXT) against 32 S. maltophilia isolates were 56.3, 71.9, 71.9 and 90.6%, respectively. Twenty-eight isolates were detected with strong biofilm formation. Antibiotic combinations, including aztreonam-clavulanic (ATM-CLA) with LVX, ceftazidime-avibactam (CZA) with LVX and SXT with TGC, exhibited potent inhibitory activity against these isolates with strong biofilm formation. The antibiotic resistance phenotype might not be fully caused by the common antibiotic-resistance or biofilm-formation gene. ConclusionS. maltophilia remained resistant to most antibiotics, including LVX and & beta;-lactam/& beta;-lactamases; however, TGC, FOS and SXT still exhibited potent activity. Although all tested S. maltophilia isolates exhibited moderate-to-strong biofilm formation, combination therapies, especially ATM-CLA with LVX, CZA with LVX and SXT with TGC, exhibited a higher inhibitory activity for these isolates.
    關聯: Frontiers in Microbiology, v.14, Article 1186669
    Appears in Collections:[藥學系(所)] 期刊論文
    [保健營養系(所) ] 期刊論文

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