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| 標題: | Prevalence of vitamin D deficiency and associated risk of all-cause and cause-specific mortality among middle-aged and older adults in the United States |
| 作者: | Wang, Ting-Yi
Wang, Hung-Wei
Jiang, Ming-Yan |
| 貢獻者: | Sin Lau Hosp, Dept Internal Med, Renal Div
Chi Mei Hosp Chiali, Dept Internal Med, Renal Div
Chi Mei Med Ctr, Dept Internal Med, Renal Div
Chia Nan Univ Pharm & Sci, Dept Pharm |
| 關鍵字: | vitamin D deficiency
vitamin D insufficiency
prevalence
mortality
pneumonia |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:53 (UTC+8) |
| 出版者: | FRONTIERS MEDIA SA |
| 摘要: | IntroductionThe prevalence of vitamin D deficiency varied among populations and regions worldwide. In addition, the association between vitamin D deficiency and health outcomes remained controversial. Our study aimed to investigate the prevalence of vitamin D deficiency and its association with mortality risk among non-institutional middle-aged and older adults in the United States. MethodThe study population included 11,119 adult participants aged between 50 and 79 years in the 2007-2016 National Health and Nutrition Examination Survey (NHANES). Vitamin D status was divided as <= 30 (severely deficient), 30.1-50 (moderately deficient), 50.1-75 (insufficient), 75.1-100 (sufficient), and > 100 nmol/L (very sufficient). NHANES data were linked to National Death Index to ascertain the survival status and cause of death. ResultsThe population aged 61.5 years (survey-weighted) and 47.9% were men. Among them, 4.6% were severely vitamin D deficient, 15.2% moderately deficient, and 33.6% insufficient. Individuals with higher vitamin D levels tended to be female, older, white people, non-smoker, non-single, more educated, with higher family income, and lower body mass index. During a median follow-up of 97.0 months, a total of 1,585 participants died (15.9 per 10,000 person-months). The crude analysis showed that vitamin D deficiency, but not vitamin D insufficiency, correlated to higher all-cause mortality risk. The association remained similar after adjusting for potential confounders, showing that vitamin D deficiency (HR: 1.38, 95% CI 1.15-1.66), but not vitamin D insufficiency (HR: 1.03, 95% CI 0.88-1.20), correlated to higher all-cause mortality risk. In addition, we showed that vitamin D deficiency was an independent risk factor for death from pneumonia (HR: 3.82, 95% CI 1.14-12.86) but not from cardiovascular diseases, cancer, or cerebrovascular diseases. ConclusionIn summary, among middle-aged and older adults in the United States, nearly 20% were vitamin D deficient. Vitamin D deficiency, but not vitamin D insufficiency, correlated to increased mortality risk. |
| 關聯: | Frontiers in Nutrition, v.10, Article 1163737 |
| 顯示於類別: | [行政單位] 456
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