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| 標題: | Elucidation of scandenolone as anti-cancer activity through impairment of the metabolic and signaling vulnerabilities in prostate cancer |
| 作者: | Basavaraj, Praveenkumar
Hsieh, Po-Fan
Jiang, Wen-Ping
Bau, Da-Tian
Huang, Guan-Jhong
Huang, Wen-Chin |
| 貢獻者: | China Med Univ, Grad Inst Biomed Sci, Sch Med
China Med Univ Hosp, Dept Urol
China Med Univ, Sch Med
Chia Nan Univ Pharm & Sci, Dept Pharm
China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab
Asia Univ, Dept Bioinformat & Med Engn
China Med Univ, Coll Chinese Med, Sch Chinese Pharmaceut Sci & Chinese Med Resources
Asia Univ, Dept Food Nutr & Hlth Biotechnol
China Med Univ, Sch Med, Int Masters Program Biomed Sci |
| 關鍵字: | Scandenolone
Lipogenesis
Cholesterogenesis
Reactive oxygen species
Anti -prostate cancer efficacy |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:35 (UTC+8) |
| 出版者: | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 摘要: | Prostate cancer (PCa) is the most prevalent men's cancer in America and Western countries. No effective ther-apies are currently available for PCa aggressiveness, including castration-resistant progression (CRPC). This study aims at evaluation of the prospective efficacy and the molecular mechanism of scandenolone (SCA), a natural isoflavone, in PCa progression. SCA suppressed cell viability and progression and induced apoptosis in PCa cells. SCA inhibited the expression of lipogenesis and cholesterogenesis related key genes. Through inhi-bition of these metabolic genes, SCA decreased the levels of fatty acids, lipid droplets and cholesterols in PCa cells. Moreover, SCA enhanced the expression of antioxidant factors, including Nrf2, HO-1, catalase and SOD-1, and reduced the ROS levels in PCa cells. Substantially, SCA displayed the potential efficacy on CRPC tumors. This paper offers a new insight into the underlying molecular basis of SCA in PCa cells. By coordinated impairment of the metabolic and signaling vulnerabilities, including lipogenesis, cholesterogenesis, ROS and the AR/PSA axis, SCA could be applied as a novel and promising remedy to cure malignant PCa. |
| 關聯: | Biomedicine & Pharmacotherapy, v.164, Article 114948 |
| 顯示於類別: | [行政單位] 456
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