Elucidation of scandenolone as anti-cancer activity through impairment of the metabolic and signaling vulnerabilities in prostate cancer

doi:10.1016/j.biopha.2023.114948

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/34853

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题名:	Elucidation of scandenolone as anti-cancer activity through impairment of the metabolic and signaling vulnerabilities in prostate cancer
作者:	Basavaraj, Praveenkumar Hsieh, Po-Fan Jiang, Wen-Ping Bau, Da-Tian Huang, Guan-Jhong Huang, Wen-Chin
贡献者:	China Med Univ, Grad Inst Biomed Sci, Sch Med China Med Univ Hosp, Dept Urol China Med Univ, Sch Med Chia Nan Univ Pharm & Sci, Dept Pharm China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab Asia Univ, Dept Bioinformat & Med Engn China Med Univ, Coll Chinese Med, Sch Chinese Pharmaceut Sci & Chinese Med Resources Asia Univ, Dept Food Nutr & Hlth Biotechnol China Med Univ, Sch Med, Int Masters Program Biomed Sci
关键词:	Scandenolone Lipogenesis Cholesterogenesis Reactive oxygen species Anti -prostate cancer efficacy
日期:	2023
上传时间:	2024-12-25 11:04:35 (UTC+8)
出版者:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
摘要:	Prostate cancer (PCa) is the most prevalent men's cancer in America and Western countries. No effective ther-apies are currently available for PCa aggressiveness, including castration-resistant progression (CRPC). This study aims at evaluation of the prospective efficacy and the molecular mechanism of scandenolone (SCA), a natural isoflavone, in PCa progression. SCA suppressed cell viability and progression and induced apoptosis in PCa cells. SCA inhibited the expression of lipogenesis and cholesterogenesis related key genes. Through inhi-bition of these metabolic genes, SCA decreased the levels of fatty acids, lipid droplets and cholesterols in PCa cells. Moreover, SCA enhanced the expression of antioxidant factors, including Nrf2, HO-1, catalase and SOD-1, and reduced the ROS levels in PCa cells. Substantially, SCA displayed the potential efficacy on CRPC tumors. This paper offers a new insight into the underlying molecular basis of SCA in PCa cells. By coordinated impairment of the metabolic and signaling vulnerabilities, including lipogenesis, cholesterogenesis, ROS and the AR/PSA axis, SCA could be applied as a novel and promising remedy to cure malignant PCa.
關聯:	Biomedicine & Pharmacotherapy, v.164, Article 114948
显示于类别:	[Dept. of Pharmacy] Periodical Articles

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