Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34853
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    CNU IR > Offices > 456 >  Item 310902800/34853
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34853


    Title: Elucidation of scandenolone as anti-cancer activity through impairment of the metabolic and signaling vulnerabilities in prostate cancer
    Authors: Basavaraj, Praveenkumar
    Hsieh, Po-Fan
    Jiang, Wen-Ping
    Bau, Da-Tian
    Huang, Guan-Jhong
    Huang, Wen-Chin
    Contributors: China Med Univ, Grad Inst Biomed Sci, Sch Med
    China Med Univ Hosp, Dept Urol
    China Med Univ, Sch Med
    Chia Nan Univ Pharm & Sci, Dept Pharm
    China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab
    Asia Univ, Dept Bioinformat & Med Engn
    China Med Univ, Coll Chinese Med, Sch Chinese Pharmaceut Sci & Chinese Med Resources
    Asia Univ, Dept Food Nutr & Hlth Biotechnol
    China Med Univ, Sch Med, Int Masters Program Biomed Sci
    Keywords: Scandenolone
    Lipogenesis
    Cholesterogenesis
    Reactive oxygen species
    Anti -prostate cancer efficacy
    Date: 2023
    Issue Date: 2024-12-25 11:04:35 (UTC+8)
    Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
    Abstract: Prostate cancer (PCa) is the most prevalent men's cancer in America and Western countries. No effective ther-apies are currently available for PCa aggressiveness, including castration-resistant progression (CRPC). This study aims at evaluation of the prospective efficacy and the molecular mechanism of scandenolone (SCA), a natural isoflavone, in PCa progression. SCA suppressed cell viability and progression and induced apoptosis in PCa cells. SCA inhibited the expression of lipogenesis and cholesterogenesis related key genes. Through inhi-bition of these metabolic genes, SCA decreased the levels of fatty acids, lipid droplets and cholesterols in PCa cells. Moreover, SCA enhanced the expression of antioxidant factors, including Nrf2, HO-1, catalase and SOD-1, and reduced the ROS levels in PCa cells. Substantially, SCA displayed the potential efficacy on CRPC tumors. This paper offers a new insight into the underlying molecular basis of SCA in PCa cells. By coordinated impairment of the metabolic and signaling vulnerabilities, including lipogenesis, cholesterogenesis, ROS and the AR/PSA axis, SCA could be applied as a novel and promising remedy to cure malignant PCa.
    Relation: Biomedicine & Pharmacotherapy, v.164, Article 114948
    Appears in Collections:[Offices] 456

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