資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/34827
|
| 標題: | Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma |
| 作者: | Ong, Khaa Hoo
Hsieh, Yao-Yu
Lai, Hong-Yue
Sun, Ding-Ping
Chen, Tzu-Ju
Huang, Steven Kuan-Hua
Tian, Yu-Feng
Chou, Chia-Ling
Shiue, Yow-Ling
Wu, Hung-Chang
Chan, Ti-Chun
Tsai, Hsin-Hwa
Li, Chien-Feng
Su, Po-An
Kuo, Yu-Hsuan |
| 貢獻者: | Chi Mei Med Ctr, Dept Surg, Div Gastroenterol & Gen Surg
Chung Hwa Univ Med Technol, Dept Med Technol
Natl Sun Yat Sen Univ, Inst Biomed Sci
Taipei Med Univ, Shuang Ho Hosp, Div Hematol & Oncol
Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med,Div Hematol & Oncol
China Med Univ, Coll Med, Sch Med, Dept Pharmacol
Chi Mei Med Ctr, Dept Clin Pathol
Chi Mei Med Ctr, Dept Surg, Div Urol
Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind
Chi Mei Med Ctr, Dept Surg, Div Colon & Rectal Surg
Natl Sun Yat Sen Univ, Inst Precis Med
Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol
Chia Nan Univ, Coll Pharm & Sci
Chi Mei Med Ctr, Dept Med Res
Natl Inst Canc Res, Natl Hlth Res Inst
China Med Univ Hosp, Dept Lab Med
Chi Mei Med Ctr, Trans Lab Precis Med
Chi Mei Med Ctr, Dept Infect Dis |
| 關鍵字: | B-VIRUS-INFECTION
RISK-FACTORS
PERIHILAR CHOLANGIOCARCINOMA
PROGRESSION
GROWTH
COMP
CONTRIBUTES
RECURRENCE
CARCINOMA
BIOMARKER |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:09 (UTC+8) |
| 出版者: | NATURE PORTFOLIO |
| 摘要: | Cartilage oligomeric matrix protein (COMP) interacts with various extracellular matrix proteins in tissues. Elevated COMP levels recently linked to worse overall survival in multiple cancer types. COMP's significance in intrahepatic cholangiocarcinoma (iCCA) remains uncertain. Here we report a retrospective study to explore COMP's impact on iCCA outcomes. We collected 182 patients' iCCA tumor tissues. COMP overexpression was associated with adverse factors like R1 resection (p = 0.008), advanced T stage (p < 0.001), large duct type (p = 0.004), and poorly differentiated histology (p = 0.002). COMP overexpression correlates with poorer DFS (HR, 3.651; p = 0.001), OS (HR, 1.827; p = 0.023), LRFS (HR, 4.077; p < 0.001), and MFS (HR, 3.718; p < 0.001). High COMP expression ties to worse overall survival (p = 0.0001), DSS (p < 0.0001), LRFS (p < 0.0001), and MFS (p < 0.0001). In conclusion, COMP overexpression links to poor prognosis and pathological features in iCCA, indicating its potential as a biomarker. |
| 關聯: | Scientific Reports, v.13, n.1, Article 17444 |
| 顯示於類別: | [行政單位] 456
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 0 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
