Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma

doi:10.1038/s41598-023-43006-z

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Title:	Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma
Authors:	Ong, Khaa Hoo Hsieh, Yao-Yu Lai, Hong-Yue Sun, Ding-Ping Chen, Tzu-Ju Huang, Steven Kuan-Hua Tian, Yu-Feng Chou, Chia-Ling Shiue, Yow-Ling Wu, Hung-Chang Chan, Ti-Chun Tsai, Hsin-Hwa Li, Chien-Feng Su, Po-An Kuo, Yu-Hsuan
Contributors:	Chi Mei Med Ctr, Dept Surg, Div Gastroenterol & Gen Surg Chung Hwa Univ Med Technol, Dept Med Technol Natl Sun Yat Sen Univ, Inst Biomed Sci Taipei Med Univ, Shuang Ho Hosp, Div Hematol & Oncol Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med,Div Hematol & Oncol China Med Univ, Coll Med, Sch Med, Dept Pharmacol Chi Mei Med Ctr, Dept Clin Pathol Chi Mei Med Ctr, Dept Surg, Div Urol Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind Chi Mei Med Ctr, Dept Surg, Div Colon & Rectal Surg Natl Sun Yat Sen Univ, Inst Precis Med Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol Chia Nan Univ, Coll Pharm & Sci Chi Mei Med Ctr, Dept Med Res Natl Inst Canc Res, Natl Hlth Res Inst China Med Univ Hosp, Dept Lab Med Chi Mei Med Ctr, Trans Lab Precis Med Chi Mei Med Ctr, Dept Infect Dis
Keywords:	B-VIRUS-INFECTION RISK-FACTORS PERIHILAR CHOLANGIOCARCINOMA PROGRESSION GROWTH COMP CONTRIBUTES RECURRENCE CARCINOMA BIOMARKER
Date:	2023
Issue Date:	2024-12-25 11:04:09 (UTC+8)
Publisher:	NATURE PORTFOLIO
Abstract:	Cartilage oligomeric matrix protein (COMP) interacts with various extracellular matrix proteins in tissues. Elevated COMP levels recently linked to worse overall survival in multiple cancer types. COMP's significance in intrahepatic cholangiocarcinoma (iCCA) remains uncertain. Here we report a retrospective study to explore COMP's impact on iCCA outcomes. We collected 182 patients' iCCA tumor tissues. COMP overexpression was associated with adverse factors like R1 resection (p = 0.008), advanced T stage (p < 0.001), large duct type (p = 0.004), and poorly differentiated histology (p = 0.002). COMP overexpression correlates with poorer DFS (HR, 3.651; p = 0.001), OS (HR, 1.827; p = 0.023), LRFS (HR, 4.077; p < 0.001), and MFS (HR, 3.718; p < 0.001). High COMP expression ties to worse overall survival (p = 0.0001), DSS (p < 0.0001), LRFS (p < 0.0001), and MFS (p < 0.0001). In conclusion, COMP overexpression links to poor prognosis and pathological features in iCCA, indicating its potential as a biomarker.
Relation:	Scientific Reports, v.13, n.1, Article 17444
Appears in Collections:	[Offices] 456

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