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| 標題: | Is Circulating Vitamin D Status Associated with the Risk of Venous Thromboembolism? A Meta-Analysis of Observational Studies |
| 作者: | Hung, Kuo-Chuan
Yang, Sheng-Hsiang
Chang, Chia-Yu
Wang, Li-Kai
Lin, Yao-Tsung
Yu, Chia-Hung
Chuang, Min-Hsiang
Chen, Jen-Yin |
| 貢獻者: | Chi Mei Med Ctr, Dept Anesthesiol
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, Coll Recreat & Hlth Management
Natl Sun Yat Sen Univ, Coll Med, Sch Med
Chi Mei Med Ctr, Dept Neurol
Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
Chi Mei Med Ctr, Dept Internal Med |
| 關鍵字: | 25-hydroxyvitamin D
vitamin D deficiency
vitamin D insufficiency
venous thromboembolism
risk factor |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:03:50 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Background: Although vitamin D is antithrombotic, associations between serum vitamin D status and the risk of venous thromboembolism (VTE) remain inconsistent. Methods: We searched the EMBASE, MEDLINE, Cochrane Library, and Google Scholar databases from inception to June 2022 to identify observational studies examining associations between vitamin D status and VTE risk in adults. The primary outcome presented as odds ratio (OR) or hazard ratio (HR) was the association of vitamin D levels with the risk of VTE. Secondary outcomes included the impacts of vitamin D status (i.e., deficiency or insufficiency), study design, and the presence of neurological diseases on the associations. Results: Pooled evidence from a meta-analysis of sixteen observational studies, including 47648 individuals published from 2013 to 2021, revealed a negative relationship between vitamin D levels and the risk of VTE either based on OR (1.74, 95% confidence interval (CI): 1.37 to 2.20, p < 0.00001; I-2 = 31%, 14 studies, 16074 individuals) or HR (1.25, 95% CI: 1.07 to 1.46, p = 0.006; I-2 = 0%, 3 studies, 37,564 individuals). This association remained significant in subgroup analyses of the study design and in the presence of neurological diseases. Compared to individuals with normal vitamin D status, an increased risk of VTE was noted in those with vitamin D deficiency (OR = 2.03, 95% CI: 1.33 to 3.11) but not with vitamin D insufficiency. Conclusions: This meta-analysis demonstrated a negative association between serum vitamin D status and the risk of VTE. Further studies are required to investigate the potential beneficial effect of vitamin D supplementation on the long-term risk of VTE. |
| 關聯: | Nutrients, v.15, n.5, Article 1113 |
| 顯示於類別: | [行政單位] 456
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