Is Circulating Vitamin D Status Associated with the Risk of Venous Thromboembolism? A Meta-Analysis of Observational Studies

doi:10.3390/nu15051113

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Title:	Is Circulating Vitamin D Status Associated with the Risk of Venous Thromboembolism? A Meta-Analysis of Observational Studies
Authors:	Hung, Kuo-Chuan Yang, Sheng-Hsiang Chang, Chia-Yu Wang, Li-Kai Lin, Yao-Tsung Yu, Chia-Hung Chuang, Min-Hsiang Chen, Jen-Yin
Contributors:	Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, Coll Recreat & Hlth Management Natl Sun Yat Sen Univ, Coll Med, Sch Med Chi Mei Med Ctr, Dept Neurol Southern Taiwan Univ Sci & Technol, Ctr Gen Educ Chi Mei Med Ctr, Dept Internal Med
Keywords:	25-hydroxyvitamin D vitamin D deficiency vitamin D insufficiency venous thromboembolism risk factor
Date:	2023
Issue Date:	2024-12-25 11:03:50 (UTC+8)
Publisher:	MDPI
Abstract:	Background: Although vitamin D is antithrombotic, associations between serum vitamin D status and the risk of venous thromboembolism (VTE) remain inconsistent. Methods: We searched the EMBASE, MEDLINE, Cochrane Library, and Google Scholar databases from inception to June 2022 to identify observational studies examining associations between vitamin D status and VTE risk in adults. The primary outcome presented as odds ratio (OR) or hazard ratio (HR) was the association of vitamin D levels with the risk of VTE. Secondary outcomes included the impacts of vitamin D status (i.e., deficiency or insufficiency), study design, and the presence of neurological diseases on the associations. Results: Pooled evidence from a meta-analysis of sixteen observational studies, including 47648 individuals published from 2013 to 2021, revealed a negative relationship between vitamin D levels and the risk of VTE either based on OR (1.74, 95% confidence interval (CI): 1.37 to 2.20, p < 0.00001; I-2 = 31%, 14 studies, 16074 individuals) or HR (1.25, 95% CI: 1.07 to 1.46, p = 0.006; I-2 = 0%, 3 studies, 37,564 individuals). This association remained significant in subgroup analyses of the study design and in the presence of neurological diseases. Compared to individuals with normal vitamin D status, an increased risk of VTE was noted in those with vitamin D deficiency (OR = 2.03, 95% CI: 1.33 to 3.11) but not with vitamin D insufficiency. Conclusions: This meta-analysis demonstrated a negative association between serum vitamin D status and the risk of VTE. Further studies are required to investigate the potential beneficial effect of vitamin D supplementation on the long-term risk of VTE.
Relation:	Nutrients, v.15, n.5, Article 1113
Appears in Collections:	[Offices] 456

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