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| 標題: | Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma |
| 作者: | Ong, Khaa Hoo
Lai, Hong-Yue
Sun, Ding-Ping
Chen, Tzu-Ju
Huang, Steven Kuan-Hua
Tian, Yu-Feng
Chou, Chia-Lin
Shiue, Yow-Ling
Chan, Ti-Chun
Li, Chien-Feng
Kuo, Yu-Hsuan |
| 貢獻者: | Chi Mei Med Ctr, Dept Surg, Div Gastroenterol & Gen Surg
Chung Hwa Univ Med Technol, Dept Med Technol
Natl Sun Yat Sen Univ, Inst Biomed Sci
China Med Univ, Sch Med, Dept Pharmacol
Chi Mei Med Ctr, Dept Clin Pathol
Chi Mei Med Ctr, Dept Surg, Div Urol
Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind
Chi Mei Med Ctr, Dept Surg, Div Colon & Rectal Surg
Natl Sun Yat Sen Univ, Inst Precis Med
Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol
Chi Mei Med Ctr, Dept Med Res
Natl Hlth Res Inst, Natl Inst Canc Res
Chi Mei Med Ctr, Trans Lab Precis Med
Chia Nan Univ, Coll Pharm & Sci |
| 關鍵字: | UBE2C
Prognosis
Cholangiocarcinoma
Ubiquitination |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:03:41 (UTC+8) |
| 出版者: | BMC |
| 摘要: | Cholangiocarcinoma is the most common malignant bile duct tumor in Southeast Asia. The special location of cholangiocarcinoma leads to it being difficult to diagnose. Currently, the progress in clinical prognosis outcomes remains abysmal owing to the lack of definitive diagnostic criteria. Therefore, uncovering the potential markers for cholangiocarcinoma is a pressing issue. Ubiquitin-conjugating enzyme E2 C (UBE2C) is a critical ubiquitination enzyme; it is involved in the tumorigenesis of various malignancies and affects the patient's prognosis. However, there is currently no relevant literature to indicate whether UBE2C is related to the clinical survival outcome of cholangiocarcinoma patients. In this report, we mined the published cholangiocarcinoma transcriptome data set (GSE26566), compared it with the ubiquitination-associated gene (GO:0016567), and identified that UBE2C was highly expressed in cholangiocarcinoma tumor tissue. Moreover, high expression of UBE2C was markedly correlated with surgical margin, primary tumor, histological variants, and histological grade. More specifically, high expression of UBE2C was negatively associated with overall survival, disease-specific survival, local recurrence-free survival, and metastasis-free survival in patients with cholangiocarcinoma. Our findings demonstrate that UBE2C may provide a potential therapeutic marker and prognostic factor for cholangiocarcinoma patients. |
| 關聯: | European Journal of Medical Research, v.28, n.1, Article 593 |
| 顯示於類別: | [行政單位] 456
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