Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma

doi:10.1186/s40001-023-01575-9

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Title:	Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma
Authors:	Ong, Khaa Hoo Lai, Hong-Yue Sun, Ding-Ping Chen, Tzu-Ju Huang, Steven Kuan-Hua Tian, Yu-Feng Chou, Chia-Lin Shiue, Yow-Ling Chan, Ti-Chun Li, Chien-Feng Kuo, Yu-Hsuan
Contributors:	Chi Mei Med Ctr, Dept Surg, Div Gastroenterol & Gen Surg Chung Hwa Univ Med Technol, Dept Med Technol Natl Sun Yat Sen Univ, Inst Biomed Sci China Med Univ, Sch Med, Dept Pharmacol Chi Mei Med Ctr, Dept Clin Pathol Chi Mei Med Ctr, Dept Surg, Div Urol Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind Chi Mei Med Ctr, Dept Surg, Div Colon & Rectal Surg Natl Sun Yat Sen Univ, Inst Precis Med Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol Chi Mei Med Ctr, Dept Med Res Natl Hlth Res Inst, Natl Inst Canc Res Chi Mei Med Ctr, Trans Lab Precis Med Chia Nan Univ, Coll Pharm & Sci
Keywords:	UBE2C Prognosis Cholangiocarcinoma Ubiquitination
Date:	2023
Issue Date:	2024-12-25 11:03:41 (UTC+8)
Publisher:	BMC
Abstract:	Cholangiocarcinoma is the most common malignant bile duct tumor in Southeast Asia. The special location of cholangiocarcinoma leads to it being difficult to diagnose. Currently, the progress in clinical prognosis outcomes remains abysmal owing to the lack of definitive diagnostic criteria. Therefore, uncovering the potential markers for cholangiocarcinoma is a pressing issue. Ubiquitin-conjugating enzyme E2 C (UBE2C) is a critical ubiquitination enzyme; it is involved in the tumorigenesis of various malignancies and affects the patient's prognosis. However, there is currently no relevant literature to indicate whether UBE2C is related to the clinical survival outcome of cholangiocarcinoma patients. In this report, we mined the published cholangiocarcinoma transcriptome data set (GSE26566), compared it with the ubiquitination-associated gene (GO:0016567), and identified that UBE2C was highly expressed in cholangiocarcinoma tumor tissue. Moreover, high expression of UBE2C was markedly correlated with surgical margin, primary tumor, histological variants, and histological grade. More specifically, high expression of UBE2C was negatively associated with overall survival, disease-specific survival, local recurrence-free survival, and metastasis-free survival in patients with cholangiocarcinoma. Our findings demonstrate that UBE2C may provide a potential therapeutic marker and prognostic factor for cholangiocarcinoma patients.
Relation:	European Journal of Medical Research, v.28, n.1, Article 593
Appears in Collections:	[Offices] 456

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